Pharmaceutical Materials

2-Amino-3-hydroxypyridine (CAS No. 16867-03-1), also known as 2-aminopyridin-3-ol, is a versatile heterocyclic compound with significant applications in pharmaceuticals and organic synthesis. Its structure features a pyridine ring substituted with an amino group at the 2-position and a hydroxyl group at the 3-position, imparting reactivity through nucleophilic substitution and hydrogen bonding. This compound serves as a key intermediate in antiretroviral drug development, particularly for HIV protease inhibitors, and is utilized in the synthesis of hair dyes, enzyme inhibitors, and azole-based pharmaceuticals. Its synthesis routes include hydrogenation of 2-nitro-3-hydroxypyridine, oxidation of 2-aminopyridine, and amination of 3-hydroxypyridine. Physically, it appears as a grayish-beige to brownish powder, soluble in methanol and ethanol, with a melting point of 168–172°C. Safety data indicates potential irritation (skin, eyes, respiratory tract) and toxicity, necessitating protective handling.

Molecular Formula: C5H6N2O

Molecular Weight: 110.11 g/mol

Appearance: Grayish-beige to brownish powder

Melting Point: 168-176°C

Usage: Intermediate in pharmaceutical and dye industries.

 

Property	Details
Chemical Name	2-Amino-3-hydroxypyridine
CAS Number	16867-03-1
Molecular Formula	C5H6N2O
Molecular Weight	110.11 g/mol
Synonyms	2-Amino-3-pyridinol, 2-Amine-3-hydroxypyridine, 3-Hydroxy-2-aminopyridine
Appearance	Off-white to light brown powder or crystalline solid
Melting Point	168-173°C
Boiling Point	385.2°C at 760 mmHg
Density	1.3±0.1 g/cm³
Solubility	Soluble in methanol and ethanol
Flash Point	186.8±23.7°C
Refractive Index	1.651 (estimate)
Applications	Used as an intermediate in organic synthesis; in the preparation of clinical anti-inflammatory analgesics; as a reagent in reactions to yield functionalized coumarins and 1.4-oxazines; used in dye industries for hair dye and dye synthesis; serves as a biochemical reagent for life science research
Safety	Toxic and irritating; handle with caution; store in a cool, dry place away from light

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