2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid

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Category:Chemical Intermediates   MOQ:100KG  Shipped directly from China

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Introduction

CAS No.: 5162-90-3 | Molecular Weight: 232.24 g/mol


1. Chemical Identification

Property Specification
IUPAC Name 2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid
Common Name Rebamipide
Molecular Formula C₁₂H₁₂N₂O₃
CAS No. 5162-90-3
Therapeutic Class Gastric Mucosa Protective Agent

2. Physical & Chemical Properties

Parameter Value
Appearance White to off-white crystalline powder
Purity (HPLC) ≥99%
Melting Point 290°C (dec.)
Density 1.343 g/cm³
Solubility Slightly soluble in DMSO (<10 mg/mL); practically insoluble in water
Storage 2-8°C in airtight, light-resistant container

3. Production & Supply

Parameter Detail
Annual Capacity 200 metric tons
MOQ 100g
Packaging 100g (amber glass bottle), 1kg (double PE bag), 25kg (fiber drum)
Shelf Life 36 months

4. Quality Standards

Test Specification
Purity (HPLC) ≥99.0%
Related Substances ≤1.0% total
Heavy Metals ≤10 ppm
Loss on Drying ≤0.5%
Residue on Ignition ≤0.1%

5. Pharmacological Applications

  • Mechanism of Action:
    • Stimulates prostaglandin E₂ synthesis
    • Increases gastric mucin (MUC5AC) production
    • Scavenges hydroxyl radicals
  • Clinical Indications:
    • Gastric ulcer treatment
    • Chronic gastritis management
    • NSAID-induced gastric injury prevention

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