2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid
Chemical Intermediates 2025-03-02
CAS No.: 5162-90-3 | Molecular Weight: 232.24 g/mol
1. Chemical Identification
| Property |
Specification |
| IUPAC Name |
2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid |
| Common Name |
Rebamipide |
| Molecular Formula |
C₁₂H₁₂N₂O₃ |
| CAS No. |
5162-90-3 |
| Therapeutic Class |
Gastric Mucosa Protective Agent |
2. Physical & Chemical Properties
| Parameter |
Value |
| Appearance |
White to off-white crystalline powder |
| Purity (HPLC) |
≥99% |
| Melting Point |
290°C (dec.) |
| Density |
1.343 g/cm³ |
| Solubility |
Slightly soluble in DMSO (<10 mg/mL); practically insoluble in water |
| Storage |
2-8°C in airtight, light-resistant container |
3. Production & Supply
| Parameter |
Detail |
| Annual Capacity |
200 metric tons |
| MOQ |
100g |
| Packaging |
100g (amber glass bottle), 1kg (double PE bag), 25kg (fiber drum) |
| Shelf Life |
36 months |
4. Quality Standards
| Test |
Specification |
| Purity (HPLC) |
≥99.0% |
| Related Substances |
≤1.0% total |
| Heavy Metals |
≤10 ppm |
| Loss on Drying |
≤0.5% |
| Residue on Ignition |
≤0.1% |
5. Pharmacological Applications
- Mechanism of Action:
- Stimulates prostaglandin E₂ synthesis
- Increases gastric mucin (MUC5AC) production
- Scavenges hydroxyl radicals
- Clinical Indications:
- Gastric ulcer treatment
- Chronic gastritis management
- NSAID-induced gastric injury prevention
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