2-[(5-bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene CAS NO.:1030825-20-7
Pharmaceutical Materials 2025-03-02
Catalog ID:94665
CAS NO.:1030825-20-7
MDL Number:MFCD21496340
Molecular Weight:361.27
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is a versatile organic compound primarily used as an intermediate in the synthesis of pharmaceuticals, particularly in the development of antidiabetic drugs such as canagliflozin. This compound features a bromine-substituted aromatic ring linked to a thiophene ring through a methylene bridge, with an additional fluorine-substituted aromatic ring attached to the thiophene. Its unique structure imparts valuable reactivity, making it a crucial building block in organic synthesis.
| Property | Details |
|---|---|
| CAS Number | 1030825-20-7 |
| Chemical Name | 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene |
| Synonyms | 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene, Canagliflozin intermediate |
| Molecular Formula | C18H14BrFS |
| Molecular Weight | 361.2715 g/mol |
| Appearance | Pale yellow to white powder |
| Density | 1.388 g/cm³ |
| Melting Point | 102.0-103.0 °C |
| Boiling Point | 438.3 ± 40.0 °C (predicted) |
| Flash Point | 218.9 ± 27.3 °C (predicted) |
| PSA | 28.240 Ų |
| LogP | 6.21590 |
| Uses | Pharmaceutical intermediate, particularly in the synthesis of antidiabetic drugs |
| Storage Conditions | Store in a cool, dry place, away from direct sunlight and sources of ignition. |
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