2-(5-Bromo-2-fluorobenzyl)benzothiophene Cas：1034305-17-3
Pharmaceutical Materials 2025-03-02
2-(5-Bromo-2-fluorobenzyl)benzothiophene, with the CAS number 1034305-17-3, is a versatile chemical intermediate with significant applications in the pharmaceutical industry. This compound features a benzothiophene core substituted with a 5-bromo-2-fluorobenzyl group, imparting unique physical and chemical properties.
2-(5-Bromo-2-fluorobenzyl)benzothiophene serves as a key intermediate in the synthesis of various therapeutic agents, notably Ipragliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor used for the treatment of type 2 diabetes. Its high reactivity and specificity make it an attractive building block for organic chemists. This compound is typically supplied as a white powder with high purity, and it should be stored under controlled conditions to maintain its stability.
| Compound Name | 2-(5-Bromo-2-fluorobenzyl)benzothiophene |
| CAS Number | 1034305-17-3 |
| Molecular Formula | C15H10BrFS |
| Molecular Weight | 321.21 g/mol |
| Appearance | White powder |
| Purity | Typically ≥98% |
| Applications | Pharmaceutical intermediate, particularly in the synthesis of Ipragliflozin. |
| Storage Conditions | 2-8°C, protected from light and moisture. |
| Melting Point | N/A |
| Boiling Point | 408.9±35.0°C at 760 mmHg |
| Density | 1.509±0.06 g/cm³ |
| Solubility in Water | Insoluble (1.00E-3 g/L) (25 ºC) |
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