2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Cas:898566-17-1

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Category:Pharmaceutical Materials  |  Brand:MT

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Introduction

Cas:898566-17-1

Chemical Name 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
CAS No. 898566-17-1
Molecular Formula C₁₈H₁₄FIS
Molecular Weight 408.27 g/mol
Aliases Canagliflozin intermediate; 2-(4-Fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene
Appearance Pale yellow solid or off-white powder
Purity ≥98%–99%
Density 1.533 g/cm³
Melting Point 109–110 °C
Boiling Point 450.2±45.0 °C (predicted)
Solubility Slightly soluble in methanol, sparingly soluble in DMSO
Packaging 20 kg/drum or 25 kg/cardboard drum
Storage 2–8 °C, protected from light
Synthesis Prepared via reduction of a halogenated intermediate, serving as a key step in synthesizing SGLT2 inhibitors like canagliflozin.
Applications Pharmaceutical intermediate: Used to produce canagliflozin, a drug for type 2 diabetes. Material science: Explored for functional materials due to its unique structure.
Safety Information Hazards: Harmful to aquatic life (H413), acute toxicity (H302), eye damage (H318), skin sensitization (H317). Handling: Follow lab safety protocols; avoid skin and eye contact.

 

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