2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Cas：898566-17-1
Pharmaceutical Materials 2025-03-02
Cas：898566-17-1
| Chemical Name | 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene |
| CAS No. | 898566-17-1 |
| Molecular Formula | C₁₈H₁₄FIS |
| Molecular Weight | 408.27 g/mol |
| Aliases | Canagliflozin intermediate; 2-(4-Fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene |
| Appearance | Pale yellow solid or off-white powder |
| Purity | ≥98%–99% |
| Density | 1.533 g/cm³ |
| Melting Point | 109–110 °C |
| Boiling Point | 450.2±45.0 °C (predicted) |
| Solubility | Slightly soluble in methanol, sparingly soluble in DMSO |
| Packaging | 20 kg/drum or 25 kg/cardboard drum |
| Storage | 2–8 °C, protected from light |
| Synthesis | Prepared via reduction of a halogenated intermediate, serving as a key step in synthesizing SGLT2 inhibitors like canagliflozin. |
| Applications | Pharmaceutical intermediate: Used to produce canagliflozin, a drug for type 2 diabetes. Material science: Explored for functional materials due to its unique structure. |
| Safety Information | Hazards: Harmful to aquatic life (H413), acute toxicity (H302), eye damage (H318), skin sensitization (H317). Handling: Follow lab safety protocols; avoid skin and eye contact. |
,Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
