(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol tetraacetate
Category：Pharmaceutical Materials
Introduction
2-chloro-5- (2,3,4,6-tetra-O-acetyl – β – D-glucopyranos-1-yl) -4 ‘- ethoxydiphenylmethane is an organic compound. The following is an introduction to the properties, uses, preparation methods, and safety information of the compound:
nature:
-Appearance: 2-chloro-5- (2,3,4,6-tetra-O-acetyl – β – D-glucopyranos-1-yl) -4 ‘- ethoxydiphenylmethane is a white crystalline solid.
-Solubility: It can dissolve in organic solvents such as dichloromethane and ethanol, but has poor solubility in water.
Purpose:
Manufacturing method:
The preparation of 2-chloro-5- (2,3,4,6-tetra-O-acetyl – β – D-glucopyranos-1-yl) -4 ‘- ethoxydiphenylmethane generally requires multiple reactions. A common preparation method is to first react 2,3,4,6-tetra-O-acetyl – β – D-glucopyranose with benzyl magnesium bromide to obtain the corresponding benzyl alcohol, which is then subjected to chlorination reaction with 2-chloro-5- (4 ‘- ethoxybenzyl) phenylacetone.
Security information:
-2-chloro-5- (2,3,4,6-tetra-O-acetyl – β – D-glucopyranos-1-yl) -4 ‘- ethoxydiphenylmethane should be stored in a dry, cool, and well ventilated place, away from sources of fire and oxidants.
-During the operation, appropriate personal protective equipment such as gloves, goggles, and protective clothing should be worn.
-When handling or disposing of this compound, local regulations and environmental protection requirements should be followed.
| Name | (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate |
| Synonyms | Acetyl Dapagliflozin Dapagliflozin Impurity 41 Dapagliflozin Tetracetate Dapagliflozin Intermediate 4 (1S)-1,5-Anhydro-1-C-[4-Chloro-3-[(4-Ethoxyphenyl)Methyl]Phenyl]-D-Glucitol Tetraacetate D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-, 2,3,4,6-tetraacetate, (1S)- (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-[4-chloro-3-(4-ethoxybenzyl)phenyl]tetrahydropyran-3,4,5-triyl Triacetate (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate (2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)-phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 4,(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol tetraacetate5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester |
| CAS | 461432-25-7 |
| EINECS | 930-010-9 |
| Molecular Formula | C29H33ClO10 |
| Molar Mass | 577.02 |
| Density | 1.29±0.1 g/cm3(Predicted) |
| Boling Point | 626.8±55.0 °C(Predicted) |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | Powder |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | IRRITANT |
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