17alpha-Ethynylestradiol CAS NO.57-63-6
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017313
CAS NO.57-63-6
Purity 96%
MDL NumberMFCD00003690
EINEC200-342-2
Molecular formula C20H24O2
Molecular weight 296.4034
Melting point: 180~188°C
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C20H24O2<br>- Molecular Weight: 304.42 g/mol<br>- CAS Number: 57-63-6<br>- Melting Point: 135-137 °C |
| Mechanism of Action | 17α-Ethynylestradiol is a synthetic estrogen that acts by binding to estrogen receptors in target cells. It mimics the effects of natural estrogen, regulating gene transcription and protein synthesis. It also suppresses the secretion of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) from the pituitary gland. |
| Indications | – Used in combined oral contraceptives to prevent pregnancy.<br>- Used in hormone replacement therapy (HRT) to treat symptoms of menopause.<br>- Used to treat acne, hirsutism, and other conditions related to hormonal imbalances. |
| Pharmacokinetics | – Absorption: Well-absorbed orally.<br>- Distribution: Widely distributed in tissues, with significant binding to plasma proteins.<br>- Metabolism: Metabolized in the liver to various active and inactive metabolites.<br>- Excretion: Primarily excreted in urine. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture. |
| Special Considerations | – Use with caution in patients with a history of thromboembolic disorders, liver disease, or unexplained vaginal bleeding.<br>- Regular monitoring of liver function and blood pressure is recommended. |
| Adverse Effects | – Common: Nausea, headache, breast tenderness.<br>- Serious: Thromboembolic events, liver toxicity. |
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