Pharmaceutical Materials

CAS No.13754-86-4

 

Category	Information
Basic Information
Name	1.5.6.7-Tetrahydro-4H-indol-4-one
CAS Number	13754-86-4
Molecular Formula	C8H9NO
Molecular Weight	135.16
Other Names	4-Oxo-1.5.6.7-tetrahydroindole, Tetrahydroindolone
Physical and Chemical Properties
Appearance	Light yellow crystals
Density	1.2±0.1 g/cm³
Melting Point	188-190 °C (lit.)
Boiling Point	310.6±11.0 °C at 760 mmHg
Flash Point	149.6±26.7 °C
Refractive Index	1.592
Vapor Pressure	0.0±0.7 mmHg at 25°C
Production Method	Synthesis through a series of chemical reactions involving resorcinol, potassium hydroxide, nickel-catalyzed hydrogenation, isomerization, and ring closure with ethyl bromopyruvate, followed by ammonia substitution and decarboxylation.
Usage	Intermediate in the production of psychotropic drugs (e.g., ethyldione). Also used in scientific research and as a chemical reagent.
Safety Information	Wear appropriate protective equipment such as N95 dust masks, eye shields, and gloves during handling. Store under inert gas (nitrogen or argon) at 2–8 °C.

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