1,5-Dihydroxy naphthalene CAS：83-56-7
Pharmaceutical Materials 2025-03-02
CAS Number: 83-56-7
Molecular Formula: C10H8O2
Molecular Weight: 160.17
Appearance: Grayish white or beige powder
Melting Point: 256-265°C
Solubility: Soluble in ethers and acetone, slightly soluble in alcohols and acetic acid, insoluble in water, benzene, and petroleum ether.
| Aspect | Details |
|---|---|
| Name | 1.5-Dihydroxy Naphthalene |
| Synonyms | 1.5-Naphthalenediol; Naphthalene-1.5-diol; 1.5-Dihydroxynaphthalene |
| CAS Number | 83-56-7 |
| Chemical Formula | C₁₀H₈O₂ |
| Molecular Weight | 160.17 g/mol |
| Physical Properties | – Appearance: White to off-white crystalline powder or needles |
| – Melting Point: 265°C | |
| – Solubility: Insoluble in water, benzene, and petroleum ether; soluble in ether, acetone, and ethanol (micellar solubility) | |
| Synthetic Applications | – Dye Intermediate: Key precursor for azo dyes, acid dyes, and vat dyes |
| – Pharmaceuticals: Synthesis of antiviral and anticancer agents | |
| – Photography: Used in developers for silver halide films | |
| Biological Activity | – Toxicity: LD₅₀ (oral, rat) > 5.000 mg/kg; moderate skin/eye irritant |
| – Metabolism: Excreted unchanged in urine in animal studies | |
| Industrial Production | – Process: Alkaline fusion of 1.5-naphthalenedisulfonic acid followed by acidification |
| – Yield: Typically 85–90% with methanol as a co-solvent in fusion stage | |
| Storage Conditions | – Environment: Sealed containers, protected from light and moisture |
| – Stability: Turns brown in alkaline solutions upon air exposure |
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