Chemical Information

Name: 1,3-Cyclohexanedione
Molecular Formula: C₆H₈O₂
Appearance: Light yellow to light gray powder
Solubility:

• Soluble in water, ethanol, acetone, chloroform, and boiling benzene
• Slightly soluble in ether and carbon disulfide

Applications

• Organic Synthesis: Key intermediate for herbicides sulcotrione and mesotrione.
• Analytical Chemistry: Used as an HPLC tag (high-performance liquid chromatography marker).

Storage & Handling

• Conditions:
  • Store at 2–8°C in a sealed, ventilated, dry environment.
  • Avoid contact with oxidizers.
• Stability: No decomposition under specified conditions.

Synthesis Procedure

1. Bromination: Cyclohexene + Br₂ → 1,2-Dibromohexane.
2. Dehydrobromination: Treat with NaOH/ethanol → 3,6-Dibromocyclohexene.
3. Hydrogenation: Catalytic hydrogenation → 1,3-Dibromocyclohexane.
4. Hydrolysis: Aqueous NaOH → 1,3-Cyclohexanol.
5. Oxidation: Cu-catalyzed heating with air/O₂ → 1,3-Cyclohexanedione.

Disclaimer

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