Pharmaceutical Materials

1,2,3-Trifluorobenzene, a fluorinated aromatic compound with the CAS number 1489-53-8, plays a vital role in pharmaceutical and agrochemical industries as a key intermediate. Its molecular formula, C₆H₃F₃, and molecular weight of 132.08 g/mol define its chemical structure. This compound exhibits a boiling point of 94–95°C and a density of 1.28 g/cm³ at 25°C, making it suitable for reactions requiring moderate temperatures. Its refractive index (n₂₀/D 1.423) and insolubility in water further enhance its utility in organic synthesis. As a highly flammable liquid (F), it requires storage in flammables areas and handling with caution to avoid contact with strong oxidizing agents. Its applications extend to the synthesis of drug intermediates, such as 2,3,4-trifluoronitrobenzene.

Usage： Used in the synthesis of pharmaceutical intermediates.

Packaging and Shipping： 200L/drum or as per buyer’s requirements.

Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.

Name	1,2,3-Trifluorobenzene
Synonyms	1,2,3-TrifL 1,2,3-fluorobenzene 1,2,3-Trifluorobenze 1,2,3-Trilfuorobenzene 1,2,3-TRIFLUOROBENZENE 1,2,3-Trifluorobenzene Benzene,1,2,3-trifluoro- 3-chloro-4-flurobenzonitrile
CAS	1489-53-8

1489-53-8 – Physico-chemical Properties

Molecular Formula	C6H3F3
Molar Mass	132.08
Density	1.28 g/mL at 25 °C (lit.)
Boling Point	94-95 °C (lit.)
Flash Point	25°F
Water Solubility	n20/D 1.423(lit.)
Appearance	clear liquid
Specific Gravity	1.280
Color	Colorless to Light orange to Yellow
BRN	1862388
Storage Condition	Flammables area
Stability	Stable. Highly flammable. Incompatible with strong oxidizing agents.
Refractive Index	n20/D 1.423(lit.)
Physical and Chemical Properties	Stable. Highly flammable. Incompatible with strong oxidizing agents.
Use	For the synthesis of drug intermediate, such as 2,3, 4-trifluoro nitrobenzene

Risk Codes	R11 – Highly Flammable R36/37/38 – Irritating to eyes, respiratory system and skin.
Safety Description	S16 – Keep away from sources of ignition. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S37/39 – Wear suitable gloves and eye/face protection S33 – Take precautionary measures against static discharges. S7/9 –

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