1,2,3-1H-Triazole
Pharmaceutical Materials 2025-03-02
CAS Number: 288-36-8
Molecular Formula: C2H3N3
Molecular Weight: 69.07 g/mol
Appearance: Clear colorless to yellow liquid
Usage: Used as an intermediate in the synthesis of semi-synthetic β-lactam antibiotics and pharmaceuticals.
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| Category | Details |
|---|---|
| CAS Number | 288-36-8 |
| Molecular Formula | C2H3N3 |
| Molecular Weight | 65.06 g/mol |
| Synonyms | 1H-1.2.3-Triazole; 4-Aza-1.3.5-cyclopentatriene |
| Appearance | Colorless to white crystalline solid |
| Melting Point | ~98-103 °C (may vary depending on purity and form) |
| Boiling Point | ~114-116 °C (760 mmHg, may vary) |
| Density | ~1.36 g/cm³ at 25 °C (may vary) |
| Solubility | Soluble in water, ethanol, ether, and acetone |
| Chemical Structure | Five-membered heterocyclic ring with two nitrogen atoms and one hydrogen atom |
| pKa Value | ~1.9 (conjugate acid of the tautomeric form, may vary) |
| Production Methods | Can be synthesized by the click chemistry reaction between azides and alkynes, or by the condensation of formamide derivatives |
| Applications | Used as a ligand in coordination chemistry, as a building block in organic synthesis, and in the preparation of pharmaceuticals and agrochemicals |
| Safety Information | May be harmful if swallowed or inhaled. Causes irritation to eyes and skin. Keep away from heat, sparks, and open flames. Store in a cool, dry place. |
| Risk Phrases | R22 (Harmful if swallowed), R36/37/38 (Irritating to eyes, respiratory system, and skin) |
| Safety Phrases | S26 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice), S36/37/39 (Wear suitable protective clothing, gloves, and eye/face protection) |
