1-Naphthylacetonitrile
Pharmaceutical Materials 2025-03-02
CAS Number: 132-75-2
Molecular Formula: C12H9N
Molecular Weight: 167.21 g/mol
Appearance: White crystalline powder
Melting Point: 32-35°C
Boiling Point: 323.9°C at 760 mmHg
Usage: Used in organic synthesis.
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| Attribute | Information |
|---|---|
| Chemical Name | 1-Naphthylacetonitrile |
| CAS Number | 86-57-7 |
| Synonyms | 1-(1-Naphthyl)acetonitrile; α-Naphthylacetonitrile; 2-Cyano-1-(1-naphthyl)ethane |
| Molecular Formula | C12H9N |
| Molecular Weight | 167.21 g/mol |
| Appearance | White to pale yellow crystalline solid |
| Melting Point | 77-80 °C |
| Boiling Point | 325 °C (760 mmHg) |
| Density | 1.17 g/cm³ |
| Refractive Index | 1.662 |
| Solubility | Soluble in organic solvents such as ethanol, ether, and benzene; insoluble in water |
| Chemical Structure | Consists of a naphthalene ring attached to an acetonitrile group through an ethyl linker |
| Uses | Used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It can also be used as a laboratory reagent. |
| Synthesis Methods | Prepared by the condensation of naphthalene with cyanoacetic acid or its esters, followed by decarboxylation. |
| Health Effects | May cause irritation to skin, eyes, and respiratory tract. Ingestion may be harmful. |
| Environmental Considerations | 1-Naphthylacetonitrile should be handled and disposed of according to local environmental regulations. |
| Safety Precautions | Wear appropriate protective clothing and eye protection. Keep away from heat, sparks, and open flames. Store in a cool, dry place. |
