Pharmaceutical Materials

1-Fluoronaphthalene (CAS No. 321-38-0) is a fluorinated aromatic compound with the molecular formula C₁₀H₇F and a molecular weight of 146.16 g/mol. It is widely recognized as a valuable intermediate in pharmaceutical synthesis, particularly in the production of antidepressants like Duloxetine, which targets serotonin and norepinephrine reuptake. Its fluorine atom enhances lipophilicity and metabolic stability, crucial for drug efficacy. 1-Fluoronaphthalene exhibits thermal stability, with a melting point of -13 °C and a boiling point of 215 °C. However, it is flammable and requires careful handling due to potential irritation to eyes, skin, and respiratory systems. Its role in medicinal chemistry underscores its significance in developing high-performance, low-toxicity drugs, leveraging fluorine’s unique electronic and hydrophobic properties.

Usage： Used as pharmaceutical intermediate and Pesticide intermediate.

Packaging and Shipping： 220KG/drum.

Storage: Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.

Name	1-fluoronaphthalene
Synonyms	NSC 4690 1-Fluornaftalen Fluoronaphthalene 1-fluoronaphthalene a-Fluoronaphthalene 1-fluoro-naphthalen 1-Fluoro naphthalene Duloxetine EP IMpurity G α-fluorinated naphthalene Duloxetine USP IMpurity G 1 – fluorinated naphthalene naphthyl fluoride C10H7F, α
CAS	321-38-0
EINECS	206-287-0
InChI	InChI=1/C12H9F/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9H
InChIKey	CWLKTJOTWITYSI-UHFFFAOYSA-N

Molecular Formula	C10H7F
Molar Mass	146.16
Density	1.1322 g/mL at 20 °C (lit.)
Melting Point	-13 °C (lit.)
Boling Point	215 °C (lit.)
Flash Point	150°F
Water Solubility	Not miscible or difficult to mix in water.
Solubility	slightly soluble in water, well soluble in chloroform, ethyl acetate, and methanol.
Vapor Presure	0.0392mmHg at 25°C
Appearance	Oil
Specific Gravity	1.332
Color	Colourless to Yellow
BRN	1906413
Storage Condition	Sealed in dry,Room Temperature
Stability	Stable. Incompatible with strong oxidizing agents.
Refractive Index	n20/D 1.593(lit.)
Physical and Chemical Properties	Appearance: colorless transparent liquid

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