Pharmaceutical Materials

CAS Number: 68077-26-9

Molecular Formula: C12H9ClFNO3

Molecular Weight: 269.66

Appearance: Chemical compound

Usage: Intermediate for fluorinated quinolones like norfloxacin.

Hazard: Harmful to aquatic organisms.

 

Aspect	Details
Name	1-Ethyl-7-chloro-6-fluoro-1.4-dihydro-4-oxoquinoline-3-carboxylic acid
Synonyms	7-Chloro-6-fluoro-1-ethyl-1.4-dihydro-4-oxoquinoline-3-carboxylic acid; Moxifloxacin Core Structure Precursor
CAS Number	Not explicitly listed in public databases (derivative of moxifloxacin-related chemistry)
Chemical Formula	C₁₂H₉ClFNO₃
Molecular Weight	269.66 g/mol
Physical Properties	– Appearance: Off-white to pale yellow crystalline solid
	– Solubility: Slightly soluble in water; more soluble in organic solvents (e.g., DMF, DMSO)
Synthetic Route	Derived from fluorinated quinoline intermediates via nucleophilic substitution and oxidation steps
Applications	– Pharmaceuticals: Core scaffold for fluoroquinolone antibiotics (e.g., moxifloxacin)
	– Research: Precursor for developing novel broad-spectrum antibacterials
Biological Relevance	Acts as a DNA gyrase/topoisomerase IV inhibitor, disrupting bacterial replication
Safety Precautions	– Handling: Use appropriate PPE; avoid inhalation or prolonged skin contact
	– Storage: Store in a cool, dry place away from light and moisture

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