Pharmaceutical Materials

CAS No.544-10-5

Name

1-chlorohexane

Synonyms

1-Chlorhexan

1-CHLOROHEXANE

HEXYL CHLORIDE

1-chloro-hexan

n-Hexylchlorid

N-Chlorohexane

1-chlorohexane

1-hexylchloride

hexane,1-chloro-

N-HEXYL CHLORIDE

n-hexyl chloride

1-Hexyl chloride

1-Chloro-N-Hexane

Reference Information

Application    chlorohexane is mainly used as pharmaceutical synthesis intermediates and organic synthesis intermediates, mainly used in laboratory research and development process and chemical pharmaceutical synthesis process.

Use    for synthesis of fragrance

for synthesis of fragrance

production method    1. Preparation Method: In a reaction flask equipped with a stirrer, reflux condenser and dropping funnel, add 110mL(1.5mol) of thionyl chloride, and slowly add 51G (0.5mol) of hexanol -1(2) dropwise, it was added in about 2H. During the dropwise addition, sulfur dioxide and hydrogen chloride gas evolved, and the diluted alkali was used to absorb, and the color of the reaction solution became darker. Reflux reaction 2h after the addition. It is changed to a distillation unit, and sulfoxide chloride is distilled off. Fractions from 132 to 134 °c were then collected. The resulting solution was washed with water, 10% sodium carbonate and water successively, dried with anhydrous calcium chloride, fractionated, and the fraction at 133-134 ° C. Was collected to obtain 35g of 1-chlorohexane (1) in a yield of 60%.

autoignition temperature    225°C