1-Chloro-3-fluorobenzene
Pharmaceutical Materials 2025-03-02
CAS Number: 625-98-9
Molecular Formula: C6H4ClF
Molecular Weight: 130.55 g/mol
Appearance: Colorless to light yellow transparent liquid
Usage: Mainly used as an intermediate in pharmaceuticals, pesticides, and liquid crystal materials.
| Attribute | Description |
|---|---|
| Name | 1-Chloro-3-fluorobenzene |
| CAS Number | 107-00-6 |
| Chemical Formula | C6H4ClF |
| Molecular Weight | 126.55 g/mol |
| Synonyms | m-Chlorofluorobenzene, 3-Fluorochlorobenzene, 1-Fluoro-3-chlorobenzene |
| Physical State | Colorless to pale yellow liquid with a characteristic odor |
| Density | 1.26 g/mL at 25°C |
| Refractive Index | 1.480-1.485 (20°C) |
| Boiling Point | 132-133°C (lit.) |
| Flash Point | 30°C (closed cup) |
| Solubility | Soluble in organic solvents such as ether, acetone, and benzene Sparingly soluble in water |
| Chemical Properties | Aromatic halogenated compound with a chlorine atom and a fluorine atom substituted on the benzene ring Undergoes halogen exchange reactions and aromatic substitution reactions Forms stable radicals due to the presence of fluorine, making it a useful intermediate in radical reactions |
| Applications | Used as a solvent and intermediate in organic synthesis Employed in the production of dyes, pesticides, and pharmaceuticals Also used in the synthesis of fluoroelastomers and other fluorinated polymers Serves as a starting material for the preparation of other halogenated aromatic compounds |
| Production Methods | Prepared by the chlorination of 3-fluorobenzene or the fluorination of 1-chlorobenzene Alternatively, synthesized through catalytic reactions involving benzene, chlorine, and fluorine Can also be obtained through halogen exchange reactions between chlorinated and fluorinated aromatic compounds |
| Safety Hazards | May cause eye and skin irritation Harmful if swallowed or inhaled Vapors may be toxic and flammable Keep away from heat, sparks, and open flames Use in a well-ventilated area and wear appropriate personal protective equipment |
| Storage Conditions | Store in a cool, dry place Keep container tightly closed and protected from light and moisture Store away from oxidizing agents and incompatible materials Comply with local regulations for the storage of hazardous chemicals |
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