Pharmaceutical Materials

1-Bromo-3,5-difluorobenzene, with a CAS number of 461-96-1, is a key intermediate in organic synthesis, particularly in pharmaceuticals and liquid crystal materials. Its molecular formula is C₆H₃BrF₂, with a molecular weight of 192.99 g/mol. This compound exists as a colorless to slightly yellow liquid, exhibiting a boiling point of 140°C and a melting point of -27°C. Its solubility in water is low (0.238 g/L at 20°C), but it is compatible with organic solvents. The molecule’s reactivity stems from the bromine and fluorine substituents, enabling its use in nucleophilic aromatic substitution reactions and metal-catalyzed cross-couplings. Its applications include the synthesis of GluN2C/D antagonists for neurological research and COX-2 inhibitors with anti-inflammatory and anticancer properties.

Usage: Used as intermediates in medicine or liquid crystal materials.

Packaging and Shipping： 1000KG/IBC drum; 200KG/drum or as per buyer requirment.

Storage: in a dry and ventilated warehouse; keep away from sunshine; avoid fire; avoid moisture.

Name	1-Bromo-3,5-difluorobenzene
Synonyms	3,5-Difluorobromobenzene 3,5-DIFLUOROBROMOBENZENE 1-Brom-3,5-difluorbenzol 3,5-Difluoro bromobenzene 1-BROMO-3,5-DIFLUOROBENZENE 1-Bromo-3,5-difluorobenzene 3,5-difluoro-1-bromobenzene 1-bromo-3,5-difluoro-benzene 1-Bromo-3,5-Difluoro Benzene
CAS	461-96-1
EINECS	416-710-2
InChI	InChI=1/C6H3BrF2/c7-4-1-5(8)3-6(9)2-4/h1-3H
InChIKey	JHLKSIOJYMGSMB-UHFFFAOYSA-N

Molecular Formula	C6H3BrF2
Molar Mass	192.99
Density	1.676 g/mL at 25 °C (lit.)
Melting Point	-27 °C
Boling Point	140 °C (lit.)
Flash Point	112°F
Water Solubility	0.238 g/L (20 ºC)
Solubility	0.238g/l
Vapor Presure	7.81mmHg at 25°C
Appearance	Liquid
Specific Gravity	1.686
Color	Clear colorless to light yellow
BRN	1931520
PH	6.6 (0.238g/l, H2O, 20℃)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	n20/D 1.499(lit.)
Physical and Chemical Properties	Density 1.676 melting point -27°C boiling point 140°C refractive index 1.498-1.5 flash point 45°C water-soluble 0.238g/L (20°C)
Use	For pharmaceutical or liquid crystal material intermediates

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