1-Bromo-2,5-difluorobenzene CAS No.:399-94-0
News 2025-04-07
Uses:
- Pharmaceutical Intermediate:
- Acts as a key building block in the synthesis of pharmaceuticals, particularly in the development of drugs targeting specific biochemical pathways. Its fluorinated structure enhances metabolic stability and bioavailability, making it valuable in medicinal chemistry.
- Agrochemical Intermediate:
- Utilized in the production of pesticides and herbicides, contributing to the design of agrochemicals with improved efficacy and environmental compatibility. The bromo and fluoro substituents influence the compound’s reactivity and target specificity.
- Liquid Crystal Material Intermediate:
- Serves as a precursor in the synthesis of liquid crystal materials, which are essential for displays in electronics such as LCDs. The molecular structure of 1-Bromo-2,5-difluorobenzene aids in achieving desired optical and electrical properties.
- Organic Synthesis:
- Functions as a versatile intermediate in organic chemistry, enabling the construction of complex molecular architectures through cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig) and other transformations. Its electron-withdrawing fluorine atoms and bromide leave group facilitate selective functionalization.
Physicochemical Properties:
- Appearance: Colorless to pale yellow liquid.
- Boiling Point: 58-59°C at 20 mmHg.
- Melting Point: -31°C.
- Density: 1.708 g/cm³.
- Solubility: Insoluble in water.
Safety and Handling:
- Toxicity: May cause skin and eye irritation; avoid inhalation, ingestion, and prolonged skin contact.
- Storage: Keep in a cool, dry place away from ignition sources.
- Handling: Use appropriate personal protective equipment (PPE) in a well-ventilated area.


