1-Benzylpiperidine-4-carboxaldehyde
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID829461
CAS NO.22065-85-6
Purity 95%
MDL NumberMFCD02258902
Molecular FormulaC13H17NO
Molecular Weight203.2802
Boiling point: 315.4°C (760mmHg)
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₁₃H₁₇NO<br>- Molecular Weight: 203.28 g/mol<br>- CAS Number: 22065-85-6<br>- Synonyms: 1-Benzyl-4-formylpiperidine, N-Benzylpiperidine-4-carboxaldehyde, 1-(Phenylmethyl)-4-piperidinecarboxaldehyde |
| Physical Properties | – Appearance: Colorless oil or pale yellow liquid.<br>- Melting Point: 145-149°C.<br>- Boiling Point: 315.4°C at 760 mmHg.<br>- Density: 1.026 g/mL at 25°C.<br>- Refractive Index: n 20/D 1.537.<br>- Solubility: Slightly soluble in acetone, chloroform, dichloromethane, and DMSO. |
| Mechanism of Action | – Acts as a versatile intermediate in organic synthesis.<br>- Can participate in various chemical reactions, including allylic alkylation, Grignard reactions, and fluorodenitrations. |
| Applications | – Pharmaceutical Synthesis: Used as an intermediate in the synthesis of drugs such as donepezil.<br>- Organic Synthesis: Used in the synthesis of MCH-R1 antagonists and selective α1 receptor antagonists.<br>- Dye and Pigment Production: Used to prepare efficient and stable dyes and dynamic photosensitizers for paper, fabric, and leather. |
| Synthesis | – Typically synthesized via oxidation of N-benzyl-4-piperidine methanol using oxalyl chloride and DMSO. |
| Safety Information | – GHS Classification: Acute oral toxicity (Category 3), severe eye damage (Category 1).<br>- Storage Conditions: Store in an inert atmosphere at -20°C.<br>- Hazards: Air-sensitive, may cause irritation to eyes and skin.<br>- First Aid: If inhaled, move to fresh air; if in eyes, rinse with water for at least 15 minutes. |
| Environmental Information | – WGK Germany: 3.<br>- Hazard Class: IRRITANT.<br>- Packaging Category: III. |
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