1-Benzhydrylpiperazine
Pharmaceutical Materials 2025-03-02
CAS Number: 841-77-0
Molecular Formula: C17H20N2
Molecular Weight: 252.35 g/mol
Appearance: White solid
Usage: Mainly used as an intermediate in organic and pharmaceutical synthesis, such as in the synthesis of antihistamines.
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| Attribute | Details |
|---|---|
| Name | 1-Benzhydrylpiperazine |
| CAS Number | 841-77-0 |
| Other Names | Benzhydrylpiperazine, N-(Diphenylmethyl)piperazine, 1-(Diphenylmethyl)piperazine |
| Molecular Formula | C17H20N2 |
| Molecular Weight | 252.36 g/mol |
| Appearance | White to light yellow crystalline solid |
| Solubility | Soluble in ethanol, benzene, and toluene; slightly soluble in water (0.45 g/L at 20°C) |
| Melting Point | 90-97°C (literature values may vary slightly) |
| Boiling Point | 365.1±32.0°C at 760 mmHg |
| Density | Approximately 1.1±0.1 g/cm3 |
| Flash Point | Below 110°C |
| Sensitivity | Air-sensitive; avoid exposure to dust and aerosols |
| Uses | Intermediate in pharmaceutical synthesis Used in the production of drugs such as Oxatomide (an H1-receptor antagonist) |
| Safety Information | Toxic if ingested; avoid contact with skin and eyes Refer to MSDS for detailed safety and handling instructions Store in a cool, dry place, away from oxidants |
| Preparation Methods | Can be prepared by reacting diphenylmethanol with concentrated hydrochloric acid, followed by extraction and reaction with piperazine |
