Pharmaceutical Materials

1-Acetyl-2-phenylhydrazine (1-APH), also known as N-acetylphenylhydrazine or acetylbenzenehydrazide, is an organic compound with the molecular formula C₈H₁₀N₂O and a molecular weight of 150.18 g/mol. It appears as a white to light-yellow crystalline solid, with a melting point of 128–131 °C and a boiling point of 214.1 °C at 760 mmHg. 1-APH is soluble in hot water, ethanol, and benzene but only slightly soluble in ethyl ether and cold water. It is widely used as an intermediate in organic synthesis, particularly in pharmaceuticals, pesticides, and anaerobic adhesives. Additionally, 1-APH is employed in research to induce hemolytic anemia in animal models by interacting with oxyhemoglobin to generate free radicals. Due to its toxicity, it is classified as a hazardous substance and requires careful handling under controlled conditions to prevent inhalation, skin contact, or ingestion.

 Usage： Used in organic synthesis.2. Peptide reagents, used for the protection of biochemical synthesis groups and the connection of protein peptide chains. As a condensing agent for the synthesis of triphosphate nucleosides, peptides, and esters; as well as an important intermediate for the synthesis of acyl imidazole and pyrveramide.

Packaging and Shipping： 25kg/drum.

Storage: Stored in a dry and ventilated warehouse; keep away from sunshine; avoid fire; avoid moisture.

Name	N-Acetylphenylhydrazine
Synonyms	Pyrodin Pyrodine PHENYLACETOHYDRAZIDE 1-Acetyl-2-phenylhyd 2-Phenylacetohydrazide N-Acetylphenylhydrazine N’-PHENYLACETOHYDRAZIDE Acetyl phenyl hydrazine phenylhydrazine acetate N-ACETYLHYDRAZINOBENZENE 1-Phenyl-2-acetylhydrazine 1-acetyl-2-phenylhydrazide 1-Acetyl-2-phenylhydrazine Acetic acid phenylhydrazone N-ACETYL-N’-PHENYLHYDRAZINE 1-Acetyl-2-Phenyl Hydrazine (APH) 2-Phenylacetohydrazide for synthesis
CAS	114-83-0
EINECS	204-055-3
InChI	InChI=1/C6H8N2.C2H4O2/c7-8-6-4-2-1-3-5-6;1-2(3)4/h1-5,8H,7H2;1H3,(H,3,4)
InChIKey	UICBCXONCUFSOI-UHFFFAOYSA-N

Molecular Formula	C8H10N2O
Molar Mass	150.18
Density	1.1392 (rough estimate)
Melting Point	128-131°C(lit.)
Boling Point	271.72°C (rough estimate)
Flash Point	188.7°C
Water Solubility	<0.1 g/100 mL at 19 C
Solubility	Soluble in hot water, alcohol, slightly soluble in ether.
Vapor Presure	1E-06mmHg at 25°C
Appearance	White crystal
Color	White to Light yellow to Light orange
BRN	742880
pKa	12.75±0.23(Predicted)
Storage Condition	Store at +15°C to +25°C.
Sensitive	Sensitive to light
Refractive Index	1.6180 (estimate)
MDL	MFCD00008672
Physical and Chemical Properties	Melting Point: 128 – 131 water-soluble:<0.1g/100 mL at 19 C Appearance: colorless prisms
Use	Organic synthesis. Stabilizer.

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