Pharmaceutical Materials

1-(4-methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidine-1-yl) phenyl]-4,5,6, 7-tetrahydro-1H-pyrazolo [3,4-C] Pyridine-3-carboxylic acid ethyl ester is an intermediate for the preparation of apixaban. apixaban is an antithrombotic drug. It is a direct inhibitor of factor Xa jointly developed by Bristol-Myers Squibb and Pfizer. It was approved for listing in the European Union in March 2011, and F DA approved the drug for listing in the United States in December 2012. Name: 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester CAS: 503614-91-3 Appearance: White powder Assay: ≥99% Capacity: 50mt/year Min.Package: 100gram Application: Apixaban intermediate Standard: Enterprise export

Molecular Formula: C27H28N4O5 Molecular Weight: 488.54 CAS Registry Number: 503614-91-3

Name	1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
Synonyms	Ethyl 1-(4-methoxyphenyl) -7-oxo-6-(4-(2-oxopiperidin-1-yl) -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazo ethyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxylate 1H-Pyrazolo[3,4-c]pyridine-3-carboxylicacid,4,5,6,7-tetrahydro-1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-,ethylester 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 4,5,6,7-Tetrahydro-1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1h-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1H-Pyrazolo[3,4-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-, ethyl ester
CAS	503614-91-3
EINECS	700-890-7

Molecular Formula	C27H28N4O5
Molar Mass	488.54
Density	1.34
Melting Point	175 – 180°C
Boling Point	758.7±60.0 °C(Predicted)
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	0.001Pa at 25℃
Appearance	Solid
Color	White to Pale Beige
pKa	0.78±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Use	This product is for scientific research only and shall not be used for other purposes.

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