1-(1-Ethoxyethyl)-4-pyrazoleboronic acid pinacol ester Cas：1029716-44-6
Pharmaceutical Materials 2025-03-02
1-(1-Ethoxyethyl)-4-pyrazoleboronic acid pinacol ester, with the CAS number 1029716-44-6, is a versatile organic compound that holds significant importance in the field of pharmaceutical chemistry. This compound features a pyrazole ring substituted with an ethoxyethyl group at the 1-position and a pinacol boronic ester group at the 4-position.
This unique structure provides it with excellent reactivity and selectivity, making it a valuable intermediate in the synthesis of various pharmaceutical agents. 1-(1-Ethoxyethyl)-4-pyrazoleboronic acid pinacol ester is typically a white solid with high purity and stability. It is widely used in organic synthesis, particularly in the preparation of Janus kinase (JAK) inhibitors, such as baricitinib, which are used in the treatment of inflammatory diseases.
| Product Information | Details |
|---|---|
| Compound Name | 1-(1-Ethoxyethyl)-4-pyrazoleboronic acid pinacol ester |
| CAS Number | 1029716-44-6 |
| Molecular Formula | C13H23BN2O3 |
| Molecular Weight | 266.14 g/mol |
| Physical State | White solid |
| Purity | ≥98% |
| Melting Point | N/A (Decomposes before melting) |
| Boiling Point | 353.3 ± 22.0 °C (Predicted) |
| Density | 1.06 g/cm³ |
| Solubility | Slightly soluble in DMSO and methanol |
| pKa | 1.55 ± 0.10 (Predicted) |
| Usage | Pharmaceutical intermediate, particularly in the synthesis of JAK inhibitors |
| Storage Conditions | Keep in a dark place, sealed in a dry environment at room temperature |
| Stability | Stable under recommended storage conditions |
| Hazard Information | Potential skin and eye irritant, handle with care |
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