α-Lipoic Acid CAS No.: 1077-28-7
Category：Pharmaceutical Materials
Introduction
α-Lipoic Acid Usage： Vitamin drugs, can stimulate fat metabolism.It is used for the treatment of acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes and other diseases. α-Lipoic Acid Packaging and Shipping： 25KG/Bag or drum or as per buyer requirements. α-Lipoic Acid Storage: Keep container sealed and store in cold storage. Store in an inert gas environment. Moisture proof. Keep away from incompatible materials such as oxidants: thermal, photosensitive, moisture sensitive, gas sensitive, etc.
| Name | DL-Lipoic acid |
| Synonyms | THIOOCTIC ACID DL-Lipoic acid DL-Thioctic acid DL-6-Thioctic acid TIMTEC-BB SBB003484 DL-alpha-Lipoic acid (1)-ALPHA-LIPOIC ACID DL-6,8-Dithiooctanoic acid dl-1,2-Dithiolane3-valericacid 5 MG PNPP SUBSTRATE TABLETS REAGENT GR 5-(1,2)Dithiolan-3-yl-pentanoic acid for synthesis |
| CAS | 1077-28-7 |
| EINECS | 214-071-2 |
| InChIKey | AGBQKNBQESQNJD-UHFFFAOYSA-N |
| Molecular Formula | C8H14O2S2 |
| Molar Mass | 206.33 |
| Density | 1.2888 (rough estimate) |
| Melting Point | 60-62°C |
| Boling Point | 160-165°C(lit.) |
| Flash Point | 160-165°C |
| Water Solubility | 0.9 g/L (20 ºC) |
| Solubility | Soluble in benzene, methanol, ethanol, slightly soluble in petroleum ether, almost insoluble in water |
| Appearance | Yellow crystalline powder |
| Color | Yellow |
| Merck | 14,9326 |
| BRN | 81853 |
| pKa | 4.75±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Sensitive to light |
| Refractive Index | 1.5200 (estimate) |
| MDL | MFCD00005474 |
| Physical and Chemical Properties | The appearance of alpha-lipoic acid is pale yellow powder crystals, almost tasteless, the chemical structure is 6,8 one or two DL-lipoic acid, in 6,8 between carbon disulfide bonds to form internal disulfide compounds. When reduced, the disulfide bond breaks to form dihydrodl-lipoic acid. Alpha-lipoic acid is insoluble in water but soluble in lipid solvents, which is listed as a fat-soluble vitamin; It is soluble in methanol, ethanol, chloroform, ether. |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | The long terminal repeat (LTR) of HIV-1 is the target of cellular transcription factors such as NF-κB, and serves as the promoter-enhancer for the viral genome when integrated in host DNA. α-Lipoic Acid (Alpha-Lipoic acid, ALA), a naturally occurring dithiol compound, plays an essential role in mitochondrial bioenergetics. α-Lipoic Acid reduces lipid accumulation in the liver by regulating the transcriptional factors SREBP-1, FoxO1, and Nrf2, and their downstream lipogenic targets via the activation of the SIRT1/LKB1/AMPK pathway. Treatment of cells with α-Lipoic Acid (250, 500 and 1000 μM) significantly increases the NAD + /NADH ratio in HepG2 cells (P<0.05 or P<0.01). Treatment with α-Lipoic Acid (50, 125, 250 and 500 μM) increases SIRT1 activity in HepG2 cells. α-Lipoic Acid (50, 125, 250, 500 and 1000 μM) increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells in a dose-dependent fashion. |
| In vivo study | C57BL/6J mice, divided into four groups, are fed an high-fat diet (HFD) for 24 weeks to induce nonalcoholic fatty liver disease (NAFLD) followed by daily administration of α-Lipoic Acid. Then, the effects of α-Lipoic Acid on hepatic lipid accumulation in long-term HFD-fed mice are assessed. Administration of α-Lipoic Acid (100 mg/kg or 200 mg/kg) markedly reduces visceral fat mass in mice. In addition, α-Lipoic Acid (100 mg/kg or 200 mg/kg) treatment inhibits the appetite and causes a dramatic weight loss (all P<0.05). |
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