α-Lipoic Acid CAS No.: 1077-28-7

α-Lipoic Acid Usage: Vitamin drugs, can stimulate fat metabolism.It is used for the treatment of acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes and other disease...

Introduction

α-Lipoic Acid Usage: Vitamin drugs, can stimulate fat metabolism.It is used for the treatment of acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes and other diseases. α-Lipoic Acid Packaging and Shipping: 25KG/Bag or drum or as per buyer requirements. α-Lipoic Acid Storage: Keep container sealed and store in cold storage. Store in an inert gas environment. Moisture proof. Keep away from incompatible materials such as oxidants: thermal, photosensitive, moisture sensitive, gas sensitive, etc.

Name DL-Lipoic acid
Synonyms THIOOCTIC ACID
DL-Lipoic acid
DL-Thioctic acid
DL-6-Thioctic acid
TIMTEC-BB SBB003484
DL-alpha-Lipoic acid
(1)-ALPHA-LIPOIC ACID
DL-6,8-Dithiooctanoic acid
dl-1,2-Dithiolane3-valericacid
5 MG PNPP SUBSTRATE TABLETS REAGENT GR
5-(1,2)Dithiolan-3-yl-pentanoic acid for synthesis
CAS 1077-28-7
EINECS 214-071-2
InChIKey AGBQKNBQESQNJD-UHFFFAOYSA-N

Molecular Formula C8H14O2S2
Molar Mass 206.33
Density 1.2888 (rough estimate)
Melting Point 60-62°C
Boling Point 160-165°C(lit.)
Flash Point 160-165°C
Water Solubility 0.9 g/L (20 ºC)
Solubility Soluble in benzene, methanol, ethanol, slightly soluble in petroleum ether, almost insoluble in water
Appearance Yellow crystalline powder
Color Yellow
Merck 14,9326
BRN 81853
pKa 4.75±0.10(Predicted)
Storage Condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.
Sensitive Sensitive to light
Refractive Index 1.5200 (estimate)
MDL MFCD00005474
Physical and Chemical Properties The appearance of alpha-lipoic acid is pale yellow powder crystals, almost tasteless, the chemical structure is 6,8 one or two DL-lipoic acid, in 6,8 between carbon disulfide bonds to form internal disulfide compounds. When reduced, the disulfide bond breaks to form dihydrodl-lipoic acid. Alpha-lipoic acid is insoluble in water but soluble in lipid solvents, which is listed as a fat-soluble vitamin; It is soluble in methanol, ethanol, chloroform, ether.
Use This product is for scientific research only and shall not be used for other purposes.
In vitro study The long terminal repeat (LTR) of HIV-1 is the target of cellular transcription factors such as NF-κB, and serves as the promoter-enhancer for the viral genome when integrated in host DNA. α-Lipoic Acid (Alpha-Lipoic acid, ALA), a naturally occurring dithiol compound, plays an essential role in mitochondrial bioenergetics. α-Lipoic Acid reduces lipid accumulation in the liver by regulating the transcriptional factors SREBP-1, FoxO1, and Nrf2, and their downstream lipogenic targets via the activation of the SIRT1/LKB1/AMPK pathway. Treatment of cells with α-Lipoic Acid (250, 500 and 1000 μM) significantly increases the NAD + /NADH ratio in HepG2 cells (P<0.05 or P<0.01). Treatment with α-Lipoic Acid (50, 125, 250 and 500 μM) increases SIRT1 activity in HepG2 cells. α-Lipoic Acid (50, 125, 250, 500 and 1000 μM) increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells in a dose-dependent fashion.
In vivo study C57BL/6J mice, divided into four groups, are fed an high-fat diet (HFD) for 24 weeks to induce nonalcoholic fatty liver disease (NAFLD) followed by daily administration of α-Lipoic Acid. Then, the effects of α-Lipoic Acid on hepatic lipid accumulation in long-term HFD-fed mice are assessed. Administration of α-Lipoic Acid (100 mg/kg or 200 mg/kg) markedly reduces visceral fat mass in mice. In addition, α-Lipoic Acid (100 mg/kg or 200 mg/kg) treatment inhibits the appetite and causes a dramatic weight loss (all P<0.05).

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