Rifaximin CAS NO.80621-81-4
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Category：Active Pharmaceutical Ingredients MOQ:100KG Shipped directly from China
Introduction
Catalog ID80017030
CAS NO.80621-81-4
Purity 97%
MDL NumberMFCD00864973
EINEC Molecular Formula C43H51N3O11
Molecular Weight 785.8785
| Aspect | Details |
|---|---|
| Definition | Rifaximin is a non-systemic, orally administered antibiotic that is poorly absorbed and primarily acts within the gastrointestinal tract. |
| Mechanism of Action | – It inhibits bacterial RNA synthesis by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase, preventing transcription.<br>- It has broad-spectrum activity against both Gram-positive and Gram-negative bacteria. |
| Clinical Uses | – FDA-Approved Indications:<br> – Treatment of traveler’s diarrhea caused by noninvasive strains of Escherichia coli in patients ≥12 years.<br> – Reduction of overt hepatic encephalopathy recurrence in adults.<br> – Treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.<br>- Off-Label Uses:<br> – Small intestinal bacterial overgrowth (SIBO).<br> – Diverticulitis.<br> – Inflammatory bowel disease and pouchitis.<br> – Prophylaxis of spontaneous bacterial peritonitis. |
| Dosage Forms | – Tablets: 200 mg, 550 mg. |
| Storage Conditions | Store at room temperature (68°F to 77°F or 20°C to 25°C), away from heat, moisture, and direct light. |
| Common Side Effects | – Headache, dizziness, nausea, abdominal pain.<br>- Rarely, allergic reactions or drug interactions. |
| Contraindications | – Hypersensitivity to rifaximin or other rifamycins.<br>- Not recommended for diarrhea caused by antibiotic use or invasive bacterial strains. |
| Pharmacokinetics | – Absorption: Poorly absorbed, with low systemic levels.<br>- Distribution: High concentration in the gastrointestinal tract.<br>- Metabolism: Metabolized by CYP3A4.<br>- Excretion: Primarily excreted in feces. |
| Special Considerations | – Use with caution in patients with severe liver disease.<br>- May interact with other medications, including oral contraceptives and warfarin.<br>- Safety and efficacy in children <12 years for certain indications have not been established |
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