2-Amino-5-fluorobenzoic acid CAS No.446-08-2
Names and Identifiers
Name
2-Amino-5-fluorobenzoic acid
Synonyms
NSC 513308
AURORA KA-5382
RARECHEM AL BO 2236
2-Amino-5-fluorobenzoic
5-FLUOROANTHRANILIC ACID
2-amino-5-fluorobenzoate
Anthran...
Category：Pharmaceutical Materials
Introduction
Names and Identifiers
| Name | 2-Amino-5-fluorobenzoic acid |
| Synonyms | NSC 513308 AURORA KA-5382 RARECHEM AL BO 2236 2-Amino-5-fluorobenzoic 5-FLUOROANTHRANILIC ACID 2-amino-5-fluorobenzoate Anthranilic acid, 5-fluoro- 2-AMINO-5-FLUOROBENZOIC ACID 2-aMino-5-fluorobenzoic aicd 2-Amino-5-fluorobenzoic acid 2-Amino-5-fluoroBenzoicacid97. 2-Amino-5-fluorobenzoic Acid, 5-FAA 5-Fluoroanthranilic acid, 2-Carboxy-4-fluoroaniline 2-Amino-5-fluorobenzoic acid (5-Fluoroanthranilic acid) |
| CAS | 446-08-2 |
| EINECS | 207-159-7 |
| InChI | InChI=1/C7H6FNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)/p-1 |
| InChIKey | FPQMGQZTBWIHDN-UHFFFAOYSA-N |
Physico-chemical Properties
| Molecular Formula | C7H6FNO2 |
| Molar Mass | 155.13 |
| Density | 1.3021 (estimate) |
| Melting Point | 181-183°C(lit.) |
| Boling Point | 223.67°C (rough estimate) |
| Flash Point | 146.2°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.000154mmHg at 25°C |
| Appearance | White to bright yellow powder |
| Color | Light yellow to light brown |
| BRN | 2803664 |
| pKa | 1.86±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| MDL | MFCD00055566 |
| Physical and Chemical Properties | Appearance: light yellow crystal Melting Point: 181-183 ℃ |
Risk and Safety
| Risk Codes | 36/37/38 – Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. S37/39 – Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29224999 |
| Hazard Class | IRRITANT |
Reference Information
| use | 2-amino -5-fluorobenzoic acid is a very important precursor for synthetic drugs, herbicides, plant growth regulators and quinoline fungicides. |
| medical use | 2-amino-5-fluorobenzoic acid can be used as a precursor of the virucidal agent of HIV infectious diseases; as a precursor of the antiviral agent of herpes virus; Preparation of alcinine and its analogs as hypoglycemic reagents for the treatment of diabetes; preparation of aminoquinoline as an anti-cancer reagent; preparation of triazoquinolinones and their analogs for neuroprotective agents in ischemia, hypoglycemia, cerebral vasospasm, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, atrophy, myelopathy and schizophrenia. |
| Synthesis method | Synthesis of 5-fluoro-anthranilic acid using 2-methyl-4-fluoro-nitrobenzene as the starting material. It uses Raney nickel as a catalyst, and undergoes catalytic hydrogenation reduction with 2-methyl-4-fluoronitrobenzene at 50°C. After the catalyst is filtered, the solvent is removed by distillation to obtain 5-fluoro-2-Aminotoluene is oxidized with potassium permanganate, and the crude product is filtered after acidification, and purified by alkali dissolution and acid analysis to obtain a purer final target product. |
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