Active Pharmaceutical Ingredients

Molecular Formula： C18H36N4O11,H2SO4,H2O

Molecular Weight： 601

CAS No.: 25389-94-0

It is Aminoglycoside antibiotics, mainly used for respiratory and urinary tract infections caused by most Gram-negative bacteria and some drug-resistant Staphylococcus aureus.

Description:It is a white or almost white, crystalline powder. It is soluble in about 8 parts of water, practically insoluble in acetone and in alcohol.

Application:It is Aminoglycoside antibiotics, mainly used for respiratory and urinary tract infections caused by most Gram-negative bacteria and some drug-resistant Staphylococcus aureus.

Packing and Storage:Preserve in tight container. If the substance is sterile, store in a sterile, tamper-proof container.

Minimum Order

One package

Kanamycin Monosulphate: A Veterinary Antibiotic

Kanamycin Monosulphate is an important antibiotic in veterinary medicine, utilized for treating various bacterial infections in animals.

1. General Characteristics

Aspect	Details
Classification	Aminoglycoside antibiotic
Source	Produced by Streptomyces kanamyceticus. The monosulphate form is obtained through chemical processing to enhance its solubility and stability for veterinary applications.
Formulation	Available as powders, which can be formulated into injectable solutions for parenteral use. It can also be incorporated into feed premixes for oral administration to livestock and poultry. In some cases, topical formulations may be used for treating skin infections.
Solubility	Soluble in water, which is beneficial for preparing solutions for different routes of administration. This property allows for easy preparation of injectable solutions and incorporation into drinking water or feed.

2. Mechanism of Action

Action	Explanation
Inhibition of Protein Synthesis	Kanamycin Monosulphate binds to the 30S ribosomal subunit of bacteria. This binding interferes with the initiation of protein synthesis and causes misreading of the genetic code on the mRNA. As a result, incorrect amino acids are incorporated into the growing polypeptide chain, leading to the production of non – functional proteins. The overall process disrupts normal bacterial growth and eventually leads to cell death.
Selective Activity	It has a broad – spectrum antibacterial effect, mainly targeting Gram – negative bacteria. The unique structure of the ribosomes in these bacteria allows for specific binding of kanamycin monosulphate, enabling its antibacterial action. It also shows some activity against certain Gram – positive bacteria.

3. Clinical Applications and Considerations

Category	Details
Applications	– Treating respiratory tract infections in livestock and poultry, especially those caused by Gram – negative bacteria. In poultry, it can be used against Escherichia coli and Pasteurella multocida infections. In cattle, it helps combat respiratory diseases caused by Mannheimia haemolytica. – Used to manage gastrointestinal infections in animals. It is effective against Salmonella spp. and other Gram – negative pathogens that cause diarrhea. – Treating skin and soft – tissue infections in animals. Topical applications can be used to manage infections caused by Staphylococcus spp. and Streptococcus spp.
Considerations	– Overuse can lead to the development of antibiotic – resistant bacteria. Adhering to proper dosage and treatment duration as prescribed by veterinarians is crucial. – High doses or long – term use may cause nephrotoxicity and ototoxicity in animals. Monitoring of renal function and auditory function may be necessary, especially in cases of extended treatment. – Caution is needed when using it in combination with other drugs. There may be potential drug – drug interactions, especially with other nephrotoxic drugs.

Kanamycin Monosulphate plays a significant role in maintaining the health and productivity of livestock, poultry, and other animals by effectively treating bacterial infections.

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