Spectinomycin Dihydrochloride Pentahydrate CAS 22189-32-8
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Category：Active Pharmaceutical Ingredients MOQ:100KG Shipped directly from China
Introduction
Molecular Formula：C14H24N2O7·2HCl·5H2O
CAS No.: 22189-32-8
It is produced by Streptomyces. It is an aminoglycoside fast bactericidal antibiotic composed of neutral sugar and aminocyclic alcohol glycoside bond.
Description：The product is white or off white crystalline powder. The product is easily soluble in water and almost insoluble in ethanol, chloroform or ether.
Application：It is used for the treatment of G-bacteria, mycoplasma and the combined infection of Mycoplasma and bacteria. It is mainly used to prevent and control the infection of E. coli, Salmonella, pasteurella and Mycoplasma in piglets.
Packing and Storage：Preserve in an airtight container. If the substance is sterile, store in a sterile, airtight, tamper- proof container.
Spectinomycin Dihydrochloride Pentahydrate: A Veterinary Antibiotic
Spectinomycin Dihydrochloride Pentahydrate is a crucial antibiotic in veterinary medicine for treating specific bacterial infections in animals.
1. General Characteristics
| Aspect | Details |
| Classification | Aminocyclitol antibiotic |
| Source | Produced by Streptomyces spectabilis and further processed to form the dihydrochloride pentahydrate salt |
| Formulation | Powders, which can be formulated into injectable solutions for intramuscular or subcutaneous injection. Oral formulations also exist but require specific preparations for proper absorption |
| Solubility | Soluble in water, advantageous for injectable solutions. However, solubility considerations are important for oral use |
2. Mechanism of Action
| Action | Explanation |
| Protein Synthesis Inhibition | Binds to the 30S ribosomal subunit of bacteria, disrupting the translocation step during protein synthesis. This halts the ribosome’s movement along the mRNA, preventing polypeptide chain elongation and inhibiting bacterial protein synthesis, ultimately leading to growth arrest and cell death |
| Selective Activity | Primarily targets Gram – negative bacteria, especially those causing respiratory and gastrointestinal infections in animals. Also shows some activity against certain Gram – positive bacteria and mycoplasmas |
3. Clinical Applications and Considerations
| Category | Details |
| Applications | – Treats respiratory tract infections in poultry, such as those caused by Escherichia coli, Pasteurella multocida, and Mycoplasma gallisepticum – Manages enteric infections in livestock, like diarrhea in piglets caused by pathogenic E. coli – Used in aquaculture to treat fish bacterial diseases, e.g., Aeromonas hydrophila infections |
| Considerations | – Overuse can lead to antibiotic – resistant bacteria. Veterinarians must adhere to proper dosage and treatment duration – Injection – site reactions may occur in some animals; appropriate injection techniques are crucial – Caution is needed when using with other drugs, as there may be drug – drug interactions, especially with other protein – synthesis – targeting antibiotics |
In summary, Spectinomycin Dihydrochloride Pentahydrate significantly contributes to maintaining the health and productivity of livestock, poultry, and in aquaculture by effectively treating bacterial infections.
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