MRTX849
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Category：Active Pharmaceutical Ingredients MOQ:100KG Shipped directly from China
Introduction
English Synonyms Adagrasib Catalog ID101505
CAS NO.2326521-71-3
Purity 98%
MDL NumberMFCD32263433
EINEC Molecular Formula C32H35ClFN7O2
Molecular Weight 604.127
| Category | Content |
|---|---|
| Generic Name | MRTX849 (Adagrasib) |
| Drug Class | Antineoplastic Agents (KRAS G12C inhibitor) |
| Mechanism of Action | MRTX849 is a covalent inhibitor of KRAS G12C, selectively binding to the mutant cysteine 12 in GDP-bound KRAS, thereby inhibiting downstream signaling pathways. |
| Indications | Investigated for the treatment of KRAS G12C mutant lung and colon adenocarcinomas. |
| Chemical Properties | Molecular Formula: C32H35ClFN7O2; Molecular Weight: 604.1 g/mol. |
| Development Status | Currently in clinical development, with results from Phase I/IB studies showing promising efficacy and safety profiles in patients with advanced KRAS G12C-mutated solid tumors. |
| Developer | Mirati Therapeutics |
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