MRTX849
Active Pharmaceutical Ingredients 2025-03-03
English Synonyms Adagrasib Catalog ID101505
CAS NO.2326521-71-3
Purity 98%
MDL NumberMFCD32263433
EINEC Molecular Formula C32H35ClFN7O2
Molecular Weight 604.127
| Category | Content |
|---|---|
| Generic Name | MRTX849 (Adagrasib) |
| Drug Class | Antineoplastic Agents (KRAS G12C inhibitor) |
| Mechanism of Action | MRTX849 is a covalent inhibitor of KRAS G12C, selectively binding to the mutant cysteine 12 in GDP-bound KRAS, thereby inhibiting downstream signaling pathways. |
| Indications | Investigated for the treatment of KRAS G12C mutant lung and colon adenocarcinomas. |
| Chemical Properties | Molecular Formula: C32H35ClFN7O2; Molecular Weight: 604.1 g/mol. |
| Development Status | Currently in clinical development, with results from Phase I/IB studies showing promising efficacy and safety profiles in patients with advanced KRAS G12C-mutated solid tumors. |
| Developer | Mirati Therapeutics |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
