Active Pharmaceutical Ingredients

CAS No.: 1405-41-0

It is a glycoside bactericidal antibiotic, which is connected by amino sugar and ligand. It is a sulfate of gentamicin, and its antibacterial spectrum is similar to that of kanamycin. It is mainly used for systemic or local infection caused by gram-negative bacteria such as Escherichia coli, dysentery bacilli, Klebsiella pneumoniae, Proteus and Pseudomonas aeruginosa.

Description:White or almost white crystalline powder, with hygroscopicity, easy to dissolve in water, difficult to dissolve in lipids, insoluble in organic solvents, with stable chemical properties and relatively stable to temperature and pH changes.

Application:It is a glycoside bactericidal antibiotic, which is connected by amino sugar and ligand. It is a sulfate of gentamicin, and its antibacterial spectrum is similar to that of kanamycin. It is mainly used for systemic or local infection caused by gram-negative bacteria such as Escherichia coli, dysentery bacilli, Klebsiella pneumoniae, Proteus and Pseudomonas aeruginosa

Packing and Storage:Preserve in an airtight container. If the substance is sterile, store in a sterile, airtight, tamper- proof container.

Minimum Order

One package

Gentamicin Sulphate: A Veterinary Antibiotic

Gentamicin Sulphate is an important antibiotic in veterinary medicine, widely used for treating various bacterial infections in animals.

1. General Characteristics

Aspect	Details
Classification	Aminoglycoside antibiotic
Source	Produced by Micromonospora purpurea. The sulphate form is obtained through chemical processing to enhance solubility and stability for veterinary applications.
Formulation	Available as powders, which can be formulated into injectable solutions for parenteral use, allowing for rapid delivery of the drug into the bloodstream. It can also be incorporated into feed premixes for oral administration to livestock and poultry. Additionally, there are topical formulations like creams and ointments for treating skin infections.
Solubility	Soluble in water, which is beneficial for preparing solutions for different routes of administration. This property enables easy preparation of injectable solutions and incorporation into drinking water or feed.

2. Mechanism of Action

Action	Explanation
Inhibition of Protein Synthesis	Gentamicin Sulphate binds to the 30S ribosomal subunit of bacteria. This binding interferes with the initiation of protein synthesis and causes misreading of the genetic code on the mRNA. As a result, incorrect amino acids are incorporated into the growing polypeptide chain, leading to the production of non – functional proteins. The overall process disrupts normal bacterial growth and eventually leads to cell death.
Selective Activity	It has a broad – spectrum antibacterial effect, mainly targeting Gram – negative bacteria. The unique structure of the ribosomes in these bacteria allows for specific binding of gentamicin sulphate, enabling its antibacterial action. It also shows some activity against certain Gram – positive bacteria, although it is generally more effective against Gram – negative pathogens.

3. Clinical Applications and Considerations

Category	Details
Applications	– Treating respiratory tract infections in livestock and poultry. In poultry, it can be used against Escherichia coli and Pasteurella multocida, which are common causes of respiratory diseases. In cattle, it helps combat respiratory infections caused by Mannheimia haemolytica. – Used to manage gastrointestinal infections in animals. It is effective against Salmonella spp. and other Gram – negative pathogens that cause diarrhea and intestinal disorders. – Treating skin and soft – tissue infections in animals. Topical applications can be used to address infections caused by Staphylococcus spp. and Streptococcus spp.
Considerations	– Overuse can lead to the development of antibiotic – resistant bacteria. Adhering to proper dosage and treatment duration as prescribed by veterinarians is crucial. – High doses or long – term use may cause nephrotoxicity and ototoxicity in animals. Monitoring of renal function and auditory function may be necessary, especially during extended treatment periods. – Caution is required when using it in combination with other drugs. There may be potential drug – drug interactions, especially with other nephrotoxic drugs. Combining gentamicin sulphate with such drugs may increase the risk of kidney damage.

Gentamicin Sulphate plays a vital role in maintaining the health and productivity of livestock, poultry, and other animals by effectively treating bacterial infections.

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