Vitamins

Molecular Formula: C12H19ClN4O7P2S

Molecular Weight: 460.767

CAS No.: 154-87-0

Product name:Cocarboxylase

Molecular Formula:C12H19ClN4O7P2S

Molecular Weight:460.767

CAS No.:154-87-0

Cocarboxylase, also called ThiaminePyrophosphate (TPP), is the coenzyme form of vitamin B1 (thiamine) and is formed by phosphorylation of vitamin B1 (thiamine). Thiamine pyrophosphate is sensitive to light and heat, and its dry powder is stable, but its aqueous solution is very unstable.

Description

It is white or off-white powder. It is soluble in water, the pH of the aqueous solution is acidic; insoluble in ethanol, acetone and ether.

Application

1) It is used for vitamin B1 deficiency.

Vitamin B1 plays an important role in maintaining normal nerve conduction, normal activities of the heart and digestive system. When vitamin B1 is lacking, it is easy to suffer from beriberi or polyneuritis.

2)It plays an important role in sugar metabolism.

The energy of nerve tissue is mainly supplied by sugar metabolism. Once vitamin B1 is lacking, energy supply will be impaired, and lactic acid-pyruvate will accumulate, resulting in polyneuritis, showing paresthesia, weakness of limbs, neuromuscular soreness and atrophy, and cardiac metabolism disorders. Symptoms of cardiac insufficiency such as palpitations, chest tightness, cardiac hypertrophy, liver stasis, and peripheral edema. Mild deficiency of vitamin B1 manifests itself as loss of appetite, weight loss and weakness. Cocarboxylase is used for vitamin B1 deficiency, high fever, hyperthyroidism, people with large amounts of glucose infusion, systemic infection, diabetes and polyneuritis, etc.

 

Parameter	Specification
Chemical Name	Thiamine Pyrophosphate Chloride (TPP-Cl).
CAS Number	154-87-0.
Molecular Formula	C₁₂H₁₇N₄O₄PS·HCl.
Molecular Weight	382.79 g/mol.
Appearance	White to off-white crystalline powder; hygroscopic.
Assay (HPLC)	≥98.0% (dry basis).
pH (1% Solution)	3.0–4.5.
Water Content	≤3.0% (Karl Fischer).
Heavy Metals	Pb ≤2 ppm; As ≤1 ppm; Hg ≤0.1 ppm; Cd ≤0.5 ppm (AAS/ICP-MS).
Microbiology	Total aerobic count ≤1.000 CFU/g; E. coli absent/g; yeast/mold ≤100 CFU/g.
Identification	UV spectrophotometry (λ=362 nm) or HPLC retention time.
Packaging	Sealed amber glass vials or aluminum foil bags; available in 100g or 1kg units.
Storage	Cool (<25°C), dry, light-protected; shelf life 24 months when sealed.
Certifications	USP/NF, EP compliant; GRAS status for food use.

 

20+ years export experience. If you're ready to take the next step or Request Free Samples, Leave your message below and we’ll reply soon.