Vitamins

Benfotiamine is a fat soluble vitamin B1 derivative. After intake of Benfotiamine, the maximum plasma concentration of vitamin B1 is about 5 times higher than that of vitamin B1, and the maximum bioavailability is about 3.6 times higher than that of vitamin B1, and it is higher than other fat soluble vitamin B1 derivatives. Human and animal studies have shown that the bioavailability and biological activity of Benfotiamine are higher than those of water-soluble vitamin forms.Product name:

Benfotiamine

Molecular Formula:

C19H23N4O6PS

Molecular Weight:

466.448

CAS No.:

22457-89-2

Description

Benfotiamine is pale-yellow or almost white powder; odorless. It is insoluble in water, methanol, ethanol, ether and chloroform, soluble in sodium hydroxide and sodium carbonate solution, slightly soluble in dilute hydrochloric acid solution.

Application

(1) Used for the prevention and treatment of vitamin B1 deficiency;

(2)Used for replenishment when the demand for vitamin B1 is increased and the intake is insufficient from food;

(3) Used for the treatment of non-alcoholic Wernicke encephalopathy;

(4) Used for the treatment of beriberi;

(5) Used for the treatment of the following diseases, it is presumed to be associated with vitamin B1 deficiency and metabolic disorders, such as: neuralgia; muscle pain, joint pain; peripheral neuritis, peripheral nerve palsy; myocardial metabolic disorder; constipation and other gastrointestinal motility obstacle.

Specification

Appearance

Pale-yellow or almost white powder; odorless

Identification A

IR spectra shows the similarity between sample and standard

Identification B

The retention time of the major peak corresponds with it of the reference standard.

Solution color and clearness

Colorless to pale yellow clear solution

Chloride

NMT 0.053%

Sulfate

NMT 0.011%

Heavy metals

NMT 20ppm

Loss on drying

NMT l.5%

Related substance:

Benzoic acid

NMT 0.1%

Thiamine

NMT 0.1%

Total impurities

NMT 1.0%

Purity

NLT 98.0%

Loss on Drying

Not more than 3.0 %

Residue on ignition (sulfated)

Not more than 0.20%

Assay

98.5% to101.0%

PH

5.5 to 7.0

Packing

25kg/drum or as customer’s requirements.

Storage

Preserve in well-closed containers. Stored in cool, dry and ventilated warehouse, and keep away from moisture.