Introduction
1. Overview
| Property |
Details |
| CAS Number |
15195-55-6 |
| Chemical Name |
tert-Butylhydrazine Hydrochloride |
| Synonyms |
N-tert-Butylhydrazine HCl; 2-tert-Butyl-1-hydrazine hydrochloride |
| Primary Uses |
Pharmaceutical intermediates, agrochemical synthesis, and organic synthesis |
| Production |
tert-Butylamine condensation with hydrazine, followed by HCl salt formation |
2. Chemical & Physical Properties
| Attribute |
Specification |
| Molecular Formula |
C₄H₁₂N₂·HCl |
| Molecular Weight |
124.62 g/mol |
| Appearance |
White to off-white crystalline powder |
| Solubility |
Freely soluble in water; soluble in methanol, ethanol |
| Melting Point |
148–152°C |
| Decomposition Temp. |
>180°C (with evolution of HCl) |
3. Applications
| Industry |
Role |
| Pharmaceuticals |
Key intermediate for antiviral drugs (e.g., remdesivir analogs) |
| Agrochemicals |
Synthesis of herbicides and insecticides |
| Organic Chemistry |
Building block for heterocycles (pyrazoles, triazoles) |
| Polymer Science |
Chain transfer agent in polymerization reactions |
4. Safety & Handling
| Aspect |
Guidelines |
| Hazard Classification |
Corrosive to metals; skin/eye irritant (GHS Category 2A) |
| Storage |
Inert atmosphere; cool, dry, and ventilated area (<30°C) |
| Incompatibility |
Strong oxidizers, acids (may evolve HCl gas) |
| PPE |
Gloves, goggles, and chemical-resistant apron |
5. Market Dynamics
| Region |
Growth Drivers |
| Asia-Pacific |
Expansion of generic drug manufacturing; agrochemical demand |
| Europe |
Regulatory focus on sustainable synthesis routes |
| North America |
Innovation in antiviral therapies; polymer additive development |
| Global Projection |
Expected CAGR of 5.8% (2025–2031); driven by healthcare and agriculture |
Conclusion
tert-Butylhydrazine hydrochloride is a critical intermediary for high-value pharmaceuticals and crop protection agents. Its HCl salt form enhances stability and reactivity in synthesis, making it a preferred reagent in scalable processes. Market growth is underpinned by rising demand for antiviral therapies and sustainable agrochemicals, positioning this compound as a linchpin in modern chemical innovation.
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