
Spectinomycin Sulfate Tetrahydrate CAS 64058-48-6
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Category:Active Pharmaceutical Ingredients
Introduction
Molecular Formula:C14H26N2O11S, 4H2O
CAS No.: 64058-48-6
It is a broad-spectrum antibiotic, which has strong inhibitory ability against gram-positive and negative bacteria. It is effective against Staphylococcus aureus, hemolytic streptococcus, Diplococcus pneumoniae, Proteus vulgaris, pneumoniae, Mycoplasma microplasma and some isolated bacteria.
Description:It is white or off white crystalline powder, easily soluble in water, and the pH of 1% solution is 3.8–5.6.
Application:This product has medium antibacterial effect on aerobic gram-negative bacteria such as E. coli, Klebsiella, Enterobacteriaceae, proteus, Acinetobacter, Haemophilus influenzae and morganobacter, and is especially effective on Neisseria gonorrhoeae.
Packing and Storage:Preserve in an airtight container. If the substance is sterile, store in a sterile, airtight, tamper- proof container.
Spectinomycin Sulfate Tetrahydrate: A Veterinary Antibiotic
Spectinomycin Sulfate Tetrahydrate is an important antibiotic in veterinary medicine, used for treating specific bacterial infections in animals.
1. General Information
Aspect | Details |
Classification | Aminocyclitol antibiotic |
Source | Produced by Streptomyces spectabilis |
Formulation | Available as powders, injectable solutions. It can be formulated for intramuscular or subcutaneous injection in animals. |
Solubility | Soluble in water, which is convenient for preparing injectable formulations. However, for oral use in some cases, specific formulations may be required to ensure proper absorption. |
2. Mechanism of Action
Action | Explanation |
Inhibition of Protein Synthesis | Spectinomycin Sulfate Tetrahydrate binds to the 30S ribosomal subunit of bacteria. This binding interferes with the translocation process during protein synthesis. It prevents the ribosome from moving along the mRNA, halting the elongation of the polypeptide chain. As a result, bacterial protein synthesis is inhibited, leading to growth arrest and eventual cell death. |
Selective Activity | It mainly targets Gram – negative bacteria, especially those causing respiratory and gastrointestinal infections in animals. The unique structure of the ribosomes in these bacteria allows for specific binding of spectinomycin sulfate tetrahydrate, enabling its antibacterial effect. It also shows some activity against certain Gram – positive bacteria and mycoplasmas. |
3. Clinical Applications and Considerations
Category | Details |
Applications | – Treating respiratory tract infections in poultry, such as those caused by Escherichia coli, Pasteurella multocida, and Mycoplasma gallisepticum. In poultry, it can help control airsacculitis and other respiratory problems. – Used to manage enteric infections in livestock, for example, diarrhea in piglets caused by pathogenic Escherichia coli. – Sometimes used in aquaculture to treat bacterial diseases in fish, like Aeromonas hydrophila infections. |
Considerations | – Overuse can lead to the development of antibiotic – resistant bacteria. Veterinarians should follow proper dosage guidelines and treatment duration to minimize this risk. – Injection – site reactions may occur in some animals, such as swelling, pain, or local tissue damage. Appropriate injection techniques and site selection are important to reduce these side effects. – Caution is needed when using it in combination with other drugs, as there may be potential drug – drug interactions. For example, it may interact with other antibiotics that also target protein synthesis, leading to enhanced or altered effects. |
Spectinomycin Sulfate Tetrahydrate plays a significant role in maintaining the health and productivity of livestock, poultry, and in aquaculture by effectively treating bacterial infections.
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