Active Pharmaceutical Ingredients

Spectinomycin hydrochloride is a broad-spectrum aminocyclodextrin antibiotic that can inhibit the growth of a variety of Gram-positive and Gram-negative organisms.

Molecular Formula：C14H24N2O7·2HCl·5H2O

CAS No.: 22189-32-8

Description

Spectinomycin Dihydrochloride Pentahydrate is a white or almost white, slightly hygroscopic powder. It is freely soluble in water, very slightly soluble in ethanol (96 per cent).

Application

Spectinomycin Dihydrochloride Pentahydrate is a broad-spectrum aminocyclodextrin antibiotic, which can inhibit the growth of many Gram-positive and Gram-negative organisms.

Packing and Storage

Preserve in an airtight container. If the substance is sterile, store in a sterile, airtight, tamper- proof container.

Minimum Order

One package

Spectinomycin Hydrochloride Introduction

Item	Details
Basic Information	Spectinomycin hydrochloride is an aminocyclitol antibiotic. Its chemical formula is C₁₄H₂₄N₂O₇·2HCl. It is a white to off – white, crystalline powder. It is derived from Streptomyces spectabilis. It has good solubility in water, which is beneficial for formulating it into injectable solutions. The hydrochloride salt form is used to enhance solubility and stability in pharmaceutical preparations.
Pharmacological Action	Spectinomycin hydrochloride acts by binding to the 30S subunit of the bacterial ribosome. This binding disrupts the normal function of the ribosome, interfering with protein synthesis. However, its exact mechanism is distinct from many other aminoglycoside antibiotics. It mainly inhibits the elongation step of protein synthesis by causing misreading of the messenger RNA code, leading to the production of non – functional proteins. It has a relatively narrow – spectrum antibacterial activity, with a primary focus on Neisseria gonorrhoeae, the causative agent of gonorrhea. It is highly effective against both penicillin – sensitive and penicillin – resistant strains of Neisseria gonorrhoeae. It also shows some activity against a few other Gram – negative bacteria, such as some strains of Escherichia coli and Proteus mirabilis, but to a much lesser extent compared to its activity against Neisseria gonorrhoeae.
Clinical Applications	1. Gonorrhea Treatment: – Spectinomycin hydrochloride is mainly used as an alternative treatment for gonorrhea. In cases where penicillin or cephalosporin – based treatments are contraindicated, such as in patients with severe allergies to these drugs, spectinomycin hydrochloride can be used. – It is also used in regions where there is a high prevalence of Neisseria gonorrhoeae strains resistant to penicillins and cephalosporins. A single intramuscular injection of spectinomycin hydrochloride is often sufficient to treat uncomplicated gonorrhea. 2. Other Infections (Limited Use): – In some cases, it may be used off – label for the treatment of certain urinary tract infections caused by susceptible Gram – negative bacteria, especially when other more commonly used antibiotics are not effective. However, this is not a common indication, and its use is mainly restricted to gonorrhea treatment.
Adverse Reactions	1. Injection – Site Reactions: Pain, swelling, and induration at the injection site are common side effects. These reactions are usually mild to moderate and resolve within a few days. 2. Gastrointestinal Effects: Nausea, vomiting, diarrhea, and abdominal pain may occur, although they are relatively less common. These symptoms are usually mild and self – limiting. 3. Allergic Reactions: Allergic reactions can occur, ranging from mild rashes, itching, and hives to severe anaphylactic shock. Patients with a history of allergic reactions to spectinomycin or related compounds are at a higher risk. 4. Renal Toxicity: Although rare, in some cases, it may cause mild renal function abnormalities, such as a transient increase in serum creatinine levels. However, the overall risk of severe renal toxicity is low. 5. Neurological Effects: Rarely, it can cause dizziness, headache, and in some cases, confusion. These neurological symptoms are usually mild and resolve quickly.
Drug Interactions	1. With Other Antibiotics: There is limited data on significant interactions with other antibiotics. However, as with any antibiotic, concurrent use with other drugs that target the same bacteria may lead to overlapping effects or potential antagonism. 2. With Probenecid: Probenecid can inhibit the renal tubular secretion of spectinomycin, increasing its plasma concentration and half – life. This may enhance the antibacterial effect but also increase the risk of side effects. 3. With Nephrotoxic Drugs: Concurrent use with other nephrotoxic drugs, such as aminoglycosides or non – steroidal anti – inflammatory drugs (NSAIDs), may increase the risk of renal toxicity, although the overall risk is still relatively low.
Special Population Considerations	1. Pregnant Women: The use of spectinomycin hydrochloride during pregnancy is generally considered safe for the treatment of gonorrhea. However, as with all medications, it should only be used when clearly needed. There is limited data on its teratogenic effects in humans, but animal studies have not shown significant adverse effects on the fetus. 2. Breastfeeding Women: Spectinomycin is excreted in breast milk in small amounts. Although it is usually considered safe for breastfeeding infants, close monitoring for any adverse effects in the infant is recommended. 3. Patients with Renal Impairment: In patients with significant renal impairment, the clearance of spectinomycin may be affected. Dosage adjustment may be required, and close monitoring of serum drug levels and renal function is recommended. 4. Elderly Patients: Elderly patients may be more sensitive to the side effects of spectinomycin hydrochloride, especially injection – site reactions and gastrointestinal effects. Close monitoring and appropriate dosing adjustments are needed.

 

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.