Active Pharmaceutical Ingredients

Catalog ID80017081

CAS NO.50-55-5

Purity 98+%

MDL NumberMFCD00005091

EINEC200-047-9

Molecular Formula C33H40N2O9

Molecular Weight 608.6787

Aspect	Details
Chemical Structure	– Molecular Formula: C₃₃H₄₀N₂O₉<br>- Molecular Weight: 608.24
Mechanism of Action	– Reserpine is an alkaloid that inhibits the storage of catecholamines and serotonin in nerve cells by binding to storage vesicles.<br>- It depletes catecholamines, leading to reduced sympathetic activity in the central nervous system (CNS) and peripheral nervous system.
Clinical Uses	– Historically used as an antihypertensive agent to lower blood pressure.<br>- Also used as a tranquilizer and sedative.<br>- Has been studied for its potential as a radioprotective agent.
Pharmacokinetics	– Distribution: Widely distributed into the brain, liver, spleen, kidney, and adipose tissue.<br>- Half-Life: Elimination half-life ranges from 45 to 168 hours in plasma; terminal elimination half-life in whole blood can be up to 386 hours.<br>- Metabolism: Primarily eliminated unchanged in feces; metabolites include methylreserpate and trimethoxybenzoic acid.
Physical Properties	– Appearance: White or pale-buff to yellow odorless powder.<br>- Solubility: Practically insoluble in water; freely soluble in chloroform, methylene chloride, and glacial acetic acid; slightly soluble in methanol, ethanol, acetone, ether, and weak solutions of acetic and citric acids.<br>- Melting Point: 25.2°C.
Storage Conditions	Stable under normal storage conditions but is subject to oxidation and hydrolysis.
Toxicity	– Carcinogenicity: Reasonably anticipated to be a human carcinogen based on animal studies.<br>- Human Toxicity: Nausea, vomiting, hypotension, sedation, and coma have been reported in cases of poisoning.
Regulatory Status	– Listed in the Second Annual Report on Carcinogens (1981) as reasonably anticipated to be a human carcinogen.<br>- Currently used in limited medical applications due to its potential carcinogenicity and availability of safer alternatives.
Historical Use	– Extracted from the roots of Rauwolfia serpentina, a plant used in traditional Hindu medicine for centuries.<br>- Used historically for hypertension, insomnia, and other conditions

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