Active Pharmaceutical Ingredients

Molecular Formula：C23H46N6O13,xH2SO4

Molecular Weight： 615

CAS No.: 1405-10-3

Neomycin sulfate is an aminoglycoside antibiotic. The product has good antibacterial effect on Staphylococcus (methicillin sensitive strain), Corynebacterium, Escherichia coli, Klebsiella, Proteus and other Enterobacteriaceae bacteria, and has poor activity on Streptococcus, Streptococcus pneumoniae and Enterococcus in each group. Pseudomonas aeruginosa and anaerobic bacteria are resistant to this product.

Description:It is white or off white powder; Odorless; Very easy to induce humidity; The aqueous solution shows right optical rotation. The product is very soluble in water and almost insoluble in ethanol, ether, acetone or chloroform.

Application:It is a broad-spectrum antibiotic. It has good effects on Staphylococcus aureus, Diphtheria Bacillus and anthrax bacillus.

Packing and Storage:Preserve in tight, light-resistant containers.

Minimum Order

One package

Neomycin Sulphate: A Veterinary Antibiotic

Neomycin Sulphate is an important antibiotic in veterinary medicine, used to treat a range of bacterial infections in animals.

1. General Characteristics

Aspect	Details
Classification	Aminoglycoside antibiotic
Source	Produced by Streptomyces fradiae. The sulphate form is obtained through chemical processing to enhance its stability and solubility in certain applications.
Formulation	Available as powders, which can be incorporated into feed premixes for oral administration to livestock and poultry. Also comes in topical creams and ointments for treating skin infections. Injectable forms may be used in specific cases but are less common due to potential toxicity concerns.
Solubility	Soluble in water, which is beneficial for preparing solutions for oral or topical use. However, for injectable use, strict control of formulation and dosage is required due to its relatively high toxicity.

2. Mechanism of Action

Action	Explanation
Inhibition of Protein Synthesis	Neomycin Sulphate binds to the 30S ribosomal subunit of bacteria. This binding interferes with the initiation of protein synthesis and causes misreading of the genetic code on the mRNA. As a result, incorrect amino acids are incorporated into the growing polypeptide chain, leading to the production of non – functional proteins. The overall process disrupts normal bacterial growth and eventually leads to cell death.
Selective Activity	It has a broad – spectrum antibacterial effect, mainly targeting Gram – negative bacteria. The unique structure of the ribosomes in these bacteria allows for specific binding of neomycin sulphate, enabling its antibacterial action. It also shows some activity against certain Gram – positive bacteria.

3. Clinical Applications and Considerations

Category	Details
Applications	– Treating gastrointestinal infections in livestock and poultry. It is effective against Escherichia coli, Salmonella spp., and other Gram – negative pathogens that cause diarrhea and other intestinal problems. In poultry, it can help control colibacillosis. – Used to treat skin and soft – tissue infections in animals. Topical applications are often used to manage infections caused by Staphylococcus spp. and Streptococcus spp. – In some cases, used in aquaculture to treat bacterial diseases in fish, such as Aeromonas hydrophila infections.
Considerations	– Overuse can lead to the development of antibiotic – resistant bacteria. Adhering to proper dosage and treatment duration as prescribed by veterinarians is crucial. – High doses or long – term use may cause nephrotoxicity and ototoxicity in animals. Monitoring of renal function and auditory function may be necessary, especially in cases of extended treatment. – Caution is required when using it in combination with other drugs. There may be potential drug – drug interactions, especially with other nephrotoxic drugs.

Neomycin Sulphate plays a significant role in maintaining the health and productivity of livestock, poultry, and in aquaculture by effectively treating bacterial infections.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.