Methotrexate
Active Pharmaceutical Ingredients 2025-03-03
Molecular Formula: C20H22N8O5
Molecular Weight: 454.4
CAS No.: 59-05-2
Methotrexate is a drug used to treat cancer, also known as cytotoxin. In order to reduce its cytotoxicity, it can be used together with calcium formyl tetrahydrofolate. It is also an immunosuppressant, which can alleviate the process of rheumatism. It has a particularly good therapeutic effect on synovitis of rheumatoid arthritis. It is one of the drugs most used by patients with rheumatoid diseases.
Description
Orange yellow crystalline powder. Melting point 185-204 ℃. Easily soluble in dilute alkali, acid or alkali metal carbonate solution, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, ether.
Application
For acute lymphoid leukemia, lymphoma, malignant hydatidiform mole, choriocarcinoma, squamous cell carcinoma, lung cancer, cervical cancer, breast cancer and osteosarcoma, etc
Minimum Order
One package
| Name | Methotrexate |
| Synonyms | Mtx
Antifolan |
Physico-chemical Properties
| Molecular Formula | C20H22N8O5 |
| Molar Mass | 454.45 |
| Density | 1.4080 (rough estimate) |
| Melting Point | 195°C |
| Boling Point | 561.26°C (rough estimate) |
| Specific Rotation(α) | +17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis) |
| Flash Point | 11℃ |
| Water Solubility | Insoluble. <0.1 g/100 mL at 19 ºC |
| Solubility | Easily soluble in dilute alkali, acid or alkali metal carbonate solution, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, ether. |
| Appearance | Yellow crystalline powder |
| Merck | 14,5985 |
| BRN | 70669 |
| pKa | pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Stability | Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below. |
| Sensitive | Light Sensitive & Hygroscopic |
| Refractive Index | 1.6910 (estimate) |
| MDL | MFCD00064370 |
| Physical and Chemical Properties | Orange-yellow crystalline powder. Melting point 185-204 °c. Soluble in dilute alkali, acid or alkali metal carbonate solution, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, ether. |
| Use | Antineoplastic agents for acute leukemia, choriocarcinoma, malignant mole and psoriasis |
