Active Pharmaceutical Ingredients

Molecular Formula: C20H22N8O5

Molecular Weight: 454.4

CAS No.: 59-05-2

Methotrexate is a drug used to treat cancer, also known as cytotoxin. In order to reduce its cytotoxicity, it can be used together with calcium formyl tetrahydrofolate. It is also an immunosuppressant, which can alleviate the process of rheumatism. It has a particularly good therapeutic effect on synovitis of rheumatoid arthritis. It is one of the drugs most used by patients with rheumatoid diseases.

Description

Orange yellow crystalline powder. Melting point 185-204 ℃. Easily soluble in dilute alkali, acid or alkali metal carbonate solution, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, ether.

Application

For acute lymphoid leukemia, lymphoma, malignant hydatidiform mole, choriocarcinoma, squamous cell carcinoma, lung cancer, cervical cancer, breast cancer and osteosarcoma, etc

Minimum Order

One package

Name

Methotrexate

Synonyms

Mtx Antifolan 4-Amino-1 Amethopterin Methotrexate L-Methotrexate (+)-Amethopterin Methotrexat-Ebewe Methylaminopterin Methylaminopterine L-(+)-Amethopterin Methylpteroylglutamate 4-Amino-4-Deoxy-N(Sup10 METHOTREXATEFORINJECTION Methylpteroylglutamic Acid 4-Amino-10-Methylfolic Acid 4-Amino-N10-methylfolic acid (+)-4-Amino-10-Methylfolic Acid 4-Amino-N 10-Methylpteroyl-L-Glutamic Acid 4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID) L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI) Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI) sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate

 Physico-chemical Properties

Molecular Formula	C20H22N8O5
Molar Mass	454.45
Density	1.4080 (rough estimate)
Melting Point	195°C
Boling Point	561.26°C (rough estimate)
Specific Rotation(α)	+17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)
Flash Point	11℃
Water Solubility	Insoluble. <0.1 g/100 mL at 19 ºC
Solubility	Easily soluble in dilute alkali, acid or alkali metal carbonate solution, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, ether.
Appearance	Yellow crystalline powder
Merck	14,5985
BRN	70669
pKa	pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Stability	Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
Sensitive	Light Sensitive & Hygroscopic
Refractive Index	1.6910 (estimate)
MDL	MFCD00064370
Physical and Chemical Properties	Orange-yellow crystalline powder. Melting point 185-204 °c. Soluble in dilute alkali, acid or alkali metal carbonate solution, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, ether.
Use	Antineoplastic agents for acute leukemia, choriocarcinoma, malignant mole and psoriasis

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