Active Pharmaceutical Ingredients

Molecular Formula: C8H11N3O3S

Molecular Weight: 229.256

CAS No.: 134678-17-4

It is a nucleoside analogue and antiviral drug, which has a competitive inhibitory effect on the synthesis and extension of viral DNA strand.

Description

It is a white to off-white solid. It is soluble in water.

Application

Hepatitis B, chronic hepatitis B with hepatitis B virus replication.

Packing

20kg/drum or as customer’s requirements.

Storage

Preserve in well-closed, light-resistant container. Store at room temperature.

Minimum Order

One package

Title	Content
Introduction	Lamivudine (also known as 3TC) is a nucleoside reverse transcriptase inhibitor (NRTI) used to treat chronic hepatitis B (HBV) and human immunodeficiency virus (HIV) infections. It works by inhibiting the viral reverse transcriptase enzyme, thereby reducing viral replication.
Mechanism of Action	Lamivudine is phosphorylated within cells to its active triphosphate form, which competes with natural deoxycytidine triphosphate for incorporation into the growing viral DNA chain. This incorporation terminates the viral DNA synthesis, inhibiting viral replication.
Medical Uses	– HIV Infection: Used in combination with other antiretroviral drugs to reduce viral load and improve immune function.<br>- Chronic Hepatitis B: Used as monotherapy to reduce viral replication and improve liver function.
Dosage Forms	– Oral Tablets: Available in 150 mg and 300 mg strengths.<br>- Oral Solution: For pediatric use.
Common Side Effects	– Gastrointestinal: Nausea, vomiting, diarrhea, abdominal pain.<br>- Other: Headache, fatigue, insomnia.
Serious Side Effects	– Hepatitis B Reactivation: Severe acute exacerbations of HBV have been reported after discontinuation of lamivudine.<br>- Allergic Reactions: Severe skin reactions (e.g., Stevens-Johnson syndrome) have been reported.<br>- Hematologic: Anemia, thrombocytopenia.
Precautions	– Monitoring: Regular liver function tests, especially for patients with chronic HBV.<br>- Discontinuation: Patients coinfected with HIV and HBV should be monitored closely if lamivudine is discontinued.<br>- Pregnancy and Breastfeeding: Generally considered safe, but consult a doctor.
Storage Conditions	Store at room temperature, protect from moisture.

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