Glyphosate

Glyphosate (CAS No. 1071-83-6)  1. Basic Information IUPAC Name: N-(Phosphonomethyl)glycine Synonyms: Roundup® (Monsanto trade name) Glyphosate-isopropylammonium (common salt form) CAS Number:...

Category:Agrochemicals

Introduction

Glyphosate (CAS No. 1071-83-6) 


1. Basic Information

  • IUPAC Name: N-(Phosphonomethyl)glycine
  • Synonyms:
    • Roundup® (Monsanto trade name)
    • Glyphosate-isopropylammonium (common salt form)
  • CAS Number: 1071-83-6
  • Molecular Formula: C₃H₈NO₅P
  • Molecular Weight: 169.07 g/mol
  • Appearance: White crystalline powder
  • Odor: Odorless

2. Physical and Chemical Properties

Property Value
Melting Point 184–189°C (decomposition)
Solubility (25°C) – Water: 10.5 g/L (pH 2.5)
– Organic solvents: Insoluble in acetone, ethanol
pH (1% solution) 2.3 (acidic)
Vapor Pressure 1.31 × 10⁻⁵ mPa (25°C)
Log Pow -3.2 (highly hydrophilic)

3. Chemical Structure

     O  
     ║  
  HO-P-CH₂-NH-CH₂-COOH  
     |  
     OH

4. Hazards (GHS Classification)

  • Acute Toxicity:
    • Oral LD₅₀ (rat): >5,000 mg/kg (Category 5)
    • Dermal LD₅₀ (rabbit): >2,000 mg/kg
  • Environmental:
    • Toxic to aquatic plants (H411)
    • Not classified for bees (LD₅₀ >100 μg/bee)
  • Carcinogenicity:
    • IARC Group 2A (probable human carcinogen)
    • EPA: “Not likely carcinogenic” (2017)

5. Storage and Handling

  • Storage:
    • Keep in original containers, away from food/feed
    • Store at <30°C, protect from moisture
  • Handling:
    • Use gloves (nitrile) and dust mask
    • Avoid spray drift during application

6. Applications

  • Herbicide:
    • Non-selective weed control (inhibits EPSP synthase)
    • Used in agriculture, forestry, and urban areas
  • Crop Desiccation: Pre-harvest treatment for cereals

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