Dextran
Pharmaceutical Materials 2025-03-02
CAS Number: 9004-54-0
Molecular Formula: (C6H10O5)n
Molecular Weight: 1 kD to 2000 kD
Appearance: White or slightly yellowish powder
Solubility: Soluble in water, DMSO, formamide, etc.
Usage: Used as a plasma expander, anticoagulant, stabilizer, and in the synthesis of dextran derivatives.
| Aspect | Details |
|---|---|
| Name | Dextran |
| Chemical Formula | (C₆H₁₀O₅)ₓ |
| Molecular Weight Range | 1.000–2.000.000 Da (variable based on molecular size: high, medium, low, or small) |
| Physical State | White or off-white amorphous powder |
| Solubility | Soluble in hot water; insoluble in ethanol |
| Synthesis | Produced by fermentation of sucrose using Leuconostoc mesenteroides |
| Key Properties | – Biocompatibility: Non-toxic and biodegradable |
| – Molecular Weight Variability: Tailored for specific applications | |
| – Hydrophilicity: High water retention capacity | |
| Applications | – Medical: Plasma volume expander, antithrombotic agent |
| – Pharmaceuticals: Drug delivery systems (e.g., nanocarriers) | |
| – Research: Fluorescent labeling (e.g., Dextran-FITC) for cell tracking | |
| – Industrial: Flocculant, coating agent, and adhesive | |
| Safety Considerations | – Approvals: Listed as safe by FDA and China’s Ministry of Health |
| – Contraindications: Avoid in patients with heart/renal failure or bleeding disorders |
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