Cinepazide CAS NO.23887-46-9
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017152
CAS NO.23887-46-9
Purity 95%
MDL NumberMFCD00868266
EINEC Molecular Formula C22H31N3O5
Molecular Weight 417.4986
| Aspect | Details |
|---|---|
| Mechanism of Action | Cinepazide is a piperazine derivative that acts as a weak calcium channel blocker. It also enhances the effects of endogenous adenosine, retards adenosine degradation, inhibits platelet aggregation, reduces blood viscosity, and improves blood rheology. |
| Clinical Applications | It is widely used for treating acute ischemic stroke, sequelae of brain trauma, unstable angina, and other cerebrovascular diseases. In China, it has been approved for injection use since 2002. |
| Formulations | Originally available as a tablet, it was withdrawn in the 1990s due to an increased risk of agranulocytosis. The injectable form is currently in use. |
| Pharmacokinetics | In animal studies, intravenous injection of cinepazide (30 mg/kg) potentiates the vertebral vasodilator response to adenosine and cyclic AMP. Intravertebral injection (1-10 mg/kg) increases vertebral blood flow in a dose-related manner. |
| Clinical Trials | Several trials have been conducted, including Phase 2 studies on acute ischemic stroke patients. These studies aim to further confirm its efficacy and safety. |
| Storage Conditions | The drug should be stored at 4°C, sealed, and away from moisture. In solvent, it can be stored at -80°C for 6 months or -20°C for 1 month. |
| Dissolution Data | Soluble in DMSO (100 mg/mL) and water (50 mg/mL) with the aid of sonication. |
| Research Status | Developed by Sihuan Pharmaceutical Holdings Group Ltd., it is currently in various stages of clinical research globally |
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