Active Pharmaceutical Ingredients

Molecular Formula: Cefoperazone Sodium

Molecular Formula: C25H26N9NaO8S2

Molecular Weight : 668

CAS No.: 62893-20-3

As the third generation of cephalosporin, cefoperazone sodium is used for the treatment of various infections caused by sensitive enzyme producing bacteria, such as respiratory system, genito-urinary system, biliary tract, gastrointestinal tract, chest and abdomen, skin and soft tissue infection, and also has a good effect on influenza bacilli and the brain infection caused by meningococcus.

Description

Cefoperazone Sodium is a white or slightly yellow, hygroscopic powder. It is freely soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent). If crystalline, it shows polymorphism.

Application

Used as a cephalosporin bulk drug and intermediate, suitable for various infections caused by sensitive bacteria such as pneumonia and other lower respiratory tract infections, urinary tract infections, biliary tract infections, skin and soft tissue infections, sepsis, peritonitis, pelvic infections, etc. Should be combined with anti-anaerobic drugs.

Packing

25kg/bag or as per customer’s requirements.

Storage

Preserve in an airtight container, protected from light, at a temperature of 2°C to 8°C. If the substance is sterile, store in a sterile, airtight, tamper-proof container.

Minimum Order

One package

Cefoperazone Sodium Introduction

Item	Details
Generic Name	Cefoperazone Sodium
Trade Names	Cefobid, etc.
Classification	Third – generation cephalosporin antibiotic
Chemical Structure	It has a beta – lactam ring structure, which is characteristic of cephalosporins. The structure enables it to bind to penicillin – binding proteins (PBPs) in bacteria, interfering with cell wall synthesis.
Pharmacological Action	Cefoperazone sodium works by inhibiting the synthesis of the bacterial cell wall. It binds to specific PBPs in the bacterial cytoplasmic membrane, preventing the cross – linking of peptidoglycan chains. This leads to weakened cell walls, causing the bacteria to lyse and die. It has broad – spectrum antibacterial activity, being effective against both Gram – positive and Gram – negative bacteria.
Clinical Applications	1. Respiratory Tract Infections: Such as pneumonia caused by Klebsiella pneumoniae, Haemophilus influenzae. 2. Urinary Tract Infections: For example, infections due to Escherichia coli. 3. Intra – abdominal Infections: In cases of peritonitis often associated with mixed bacterial flora. 4. Septicemia: Can be used to treat bloodstream infections caused by susceptible organisms.
Dosage and Administration	Usually administered intravenously or intramuscularly. The dosage varies depending on the type and severity of the infection, as well as the patient’s age and renal function. For adults, the typical daily dose ranges from 2 – 4 g, divided into 2 – 4 equal doses.
Adverse Reactions	1. Gastrointestinal Effects: Nausea, vomiting, diarrhea may occur. 2. Allergic Reactions: Ranging from rashes to more severe anaphylactic shock in rare cases. 3. Hematological Effects: Prolonged bleeding time may be observed in some patients due to the drug’s interference with vitamin K metabolism.

 

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