Active Pharmaceutical Ingredients

Carboplatin is a second-generation platinum anticancer drug. Its anticancer activity is similar to that of cisplatin, but its nephrotoxicity, ototoxicity, neurotoxicity, especially gastrointestinal reactions, are significantly lower than cisplatin, and its anticancer spectrum is not as wide as cisplatin. Its mechanism of action is mainly to cause cross-linking between and within DNA strands, interfere with DNA molecules, inhibit cell DNA synthesis, and mainly act on the N-7 and O-6 atoms of guanine in DNA to produce cytotoxicity.

Molecular Formula: C6H12N2O4Pt

Molecular Weight: 371.3

CAS No.:41575-94-4

Description

This product is white or off white powder, or crystalline powder, odorless, tasteless, slightly soluble in water, insoluble in ethanol, acetone, ether, chloroform; It is easy to decompose when exposed to light.

Application

It is used to treat small cell lung cancer, ovarian cancer, testicular cancer, germ cell tumor, thyroid cancer, nasopharyngeal carcinoma, cervical cancer, non-small cell lung cancer, esophageal cancer, seminoma, bladder cancer, mesothelioma, brain tumors in children and other head and neck cancers.

Packing and Storage

Preserve in tight and light-resistant containers.

Minimum Order

One package

Aspect	Details
Mechanism of Action	Carboplatin is a platinum-based alkylating agent that forms intra- and inter-strand cross-links with DNA, leading to DNA damage and apoptosis in rapidly dividing cells.
Pharmacokinetics	Carboplatin has a linear pharmacokinetic profile with a dose-independent clearance. Its elimination half-life is typically between 2 and 6 hours in patients with normal renal function, but can extend up to 18 hours in those with impaired renal function. It is highly stable in infusion fluids without chloride but less stable in plasma and urine.
Administration	Administered intravenously, carboplatin is often used in combination with other chemotherapeutic agents. Dosing is adjusted based on the patient’s glomerular filtration rate (GFR) to account for renal clearance.
Adverse Effects	The primary dose-limiting toxicity is myelosuppression, particularly thrombocytopenia. Other side effects include nausea, vomiting, and allergic reactions.
Storage Conditions	Carboplatin injection should be stored at 20° to 25°C (68° to 77°F), with excursions permitted between 15° and 30°C (59° and 86°F). Unopened vials should be protected from light.
Special Considerations	Carboplatin is less nephrotoxic and neurotoxic compared to cisplatin, making it a preferred option for patients with compromised renal function.

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